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Literature summary for 1.21.98.4 extracted from

  • Barr, I.; Latham, J.; Iavarone, A.; Chantarojsiri, T.; Hwang, J.; Klinman, J.
    Demonstration that the radical S-adenosylmethionine (SAM) enzyme PqqE catalyzes de novo carbon-carbon cross-linking within a peptide substrate PqqA in the presence of the peptide chaperone PqqD (2016), J. Biol. Chem., 291, 8877-8884 .
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
PqqD PqqE activity is dependent on the accessory protein PqqD. The intramolecular cross-linking reaction that occurs between PqqA residues is dependent on PqqE, the peptide chaperone PqqD, and the flavodoxin reductase system Methylorubrum extorquens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a PqqA peptide + S-adenosyl-L-methionine Methylorubrum extorquens
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 a PqqA peptide with linked Glu-Tyr residues + 5'-deoxyadenosine + L-methionine
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 ?
a PqqA peptide + S-adenosyl-L-methionine Methylorubrum extorquens ATCC 14718
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 a PqqA peptide with linked Glu-Tyr residues + 5'-deoxyadenosine + L-methionine
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 ?

Organism

Organism UniProt Comment Textmining
Methylorubrum extorquens P71517
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Methylorubrum extorquens ATCC 14718 P71517
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a PqqA peptide + S-adenosyl-L-methionine
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 Methylorubrum extorquens a PqqA peptide with linked Glu-Tyr residues + 5'-deoxyadenosine + L-methionine
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 ?
a PqqA peptide + S-adenosyl-L-methionine the enzyme catalyzes the carbon-carbon bond formation between a Glu15 and Tyr19 side chain within the small peptide substrate PqqA. Intramolecular cross-linking reaction between PqqA residues Methylorubrum extorquens a PqqA peptide with linked Glu-Tyr residues + 5'-deoxyadenosine + L-methionine
-
 ?
a PqqA peptide + S-adenosyl-L-methionine
-
 Methylorubrum extorquens ATCC 14718 a PqqA peptide with linked Glu-Tyr residues + 5'-deoxyadenosine + L-methionine
-
 ?
a PqqA peptide + S-adenosyl-L-methionine the enzyme catalyzes the carbon-carbon bond formation between a Glu15 and Tyr19 side chain within the small peptide substrate PqqA. Intramolecular cross-linking reaction between PqqA residues Methylorubrum extorquens ATCC 14718 a PqqA peptide with linked Glu-Tyr residues + 5'-deoxyadenosine + L-methionine
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 ?

Synonyms

Synonyms Comment Organism
pqqE
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 Methylorubrum extorquens

Cofactor

Cofactor Comment Organism Structure
iron-sulfur centre the enzyme contains three Fe-S centers, at least two of which are present as [4Fe-4S]. PqqD interacts specifically with the radical SAM enzyme PqqE, causing a perturbation in the electronic environment around the [4Fe-4S]+ clusters Methylorubrum extorquens

General Information

General Information Comment Organism
metabolism the enzyme is involved in the pyrroloquinoline quinone biosynthetic pathway Methylorubrum extorquens