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Literature summary for 1.21.4.5 extracted from

  • Willett, W.S.; Copley, S.D.
    Identification and localization of a stable sulfenic acid in peroxide-treated tetrachlorohydroquinone dehalogenase using electrospray mass spectrometry (1996), Chem. Biol., 3, 851-857 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2,3,5,6-tetrachlorohydroquinone + 2 glutathione Sphingobium chlorophenolicum the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone. The enzyme is involved in degradation of pentachlorophenol a widely used wood preservative 2,3,6-trichlorohydroquinone + Cl- + glutathione disulfide
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?
2,3,6-trichlorohydroquinone + 2 glutathione Sphingobium chlorophenolicum the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone. The enzyme is involved in degradation of pentachlorophenol, a widely used wood preservative 2,6-dichlorohydroquinone + Cl- + glutathione disulfide
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?

Organism

Organism UniProt Comment Textmining
Sphingobium chlorophenolicum Q03520
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-

Oxidation Stability

Oxidation Stability Organism
the enzyme undergoes oxidative damage during purification which causes it to form aberrant products. The damage is reversible by treatment with dithiothreitol. Possible types of oxidative damage include an inappropriate disulfide bond, a cysteine sulfenic acid, or a methionine sulfoxide Sphingobium chlorophenolicum

Purification (Commentary)

Purification (Comment) Organism
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Sphingobium chlorophenolicum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,3,5,6-tetrachlorohydroquinone + 2 glutathione the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone. The enzyme is involved in degradation of pentachlorophenol a widely used wood preservative Sphingobium chlorophenolicum 2,3,6-trichlorohydroquinone + Cl- + glutathione disulfide
-
?
2,3,5,6-tetrachlorohydroquinone + 2 glutathione the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone Sphingobium chlorophenolicum 2,3,6-trichlorohydroquinone + Cl- + glutathione disulfide
-
?
2,3,6-trichlorohydroquinone + 2 glutathione the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone. The enzyme is involved in degradation of pentachlorophenol, a widely used wood preservative Sphingobium chlorophenolicum 2,6-dichlorohydroquinone + Cl- + glutathione disulfide
-
?
2,3,6-trichlorohydroquinone + 2 glutathione the enzyme converts tetrachlorohydroquinone to trichlorohydroquinone and trichlorohydroquinone to dichlorohydroquinone Sphingobium chlorophenolicum 2,6-dichlorohydroquinone + Cl- + glutathione disulfide
-
?

Synonyms

Synonyms Comment Organism
TCHQ dehalogenase
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Sphingobium chlorophenolicum
tetrachlorohydroquinone dehalogenase
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Sphingobium chlorophenolicum