Literature summary for 1.21.3.1 extracted from

Ge, W.; Clifton, I.J.; Howard-Jones, A.R.; Stok, J.E.; Adlington, R.M.; Baldwin, J.E.; Rutledge, P.J.
Structural studies on the reaction of isopenicillin N synthase with a sterically demanding depsipeptide substrate analogue (2009), ChemBioChem, 10, 2025-2031.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
the crystal structures of isopenicillin N synthase in complex with gamma-(L-alpha-aminoadipoyl)-(3S-methyl)-L-cysteine D-alpha-hydroxyisovaleryl ester and FeII exposed to O2 and unexposed to O2 are solved to resolutions of 2.2 and 1.65 A, respectively	Aspergillus nidulans

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Iron	-	Aspergillus nidulans

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
delta-L-alpha-aminoadipoyl-L-cysteinyl-D-valine + O2	Aspergillus nidulans	-	isopenicillin N + 2 H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Aspergillus nidulans	P05326	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
delta-L-alpha-aminoadipoyl-L-cysteinyl-D-valine + O2	-	Aspergillus nidulans	isopenicillin N + 2 H2O	-	?
N6-[(1R,2S)-1-([[(1R)-1-carboxy-2-methylpropyl]oxy]carbonyl)-2-sulfanylpropyl]-6-oxo-L-lysine + O2	substrate analogue	Aspergillus nidulans	? + H2O	-	?

Synonyms

Synonyms	Comment	Organism
IPNS	-	Aspergillus nidulans
isopenicillin N synthase	-	Aspergillus nidulans

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Release 2023.1 (January 2023)