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Literature summary for 1.21.1.1 extracted from

  • Rosenberg, I.
    Purification of iodotyrosine deiodinase from bovine thyroid (1970), Metab. Clin. Exp., 19, 785-798.
    View publication on PubMed
Search for more literature for 1.21.1.1

Activating Compound

Activating Compound Comment Organism Structure
FAD
-
 Bos taurus
FMN
-
 Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
3,5-diiodo-L-tyrosine pronounced substrate inhibition above 5 microM Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
thyroid gland
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,5-diiodo-L-tyrosine + dithionite solubilized enzyme preparations are active with dithionite, but not with NADPH. Particle-bound enzyme uses both dithionite and NADPH. At concentrations of substrate below 1 microM, 3,5-diiodo-L-tyrosine is more rapidly deiodinated than 3-iodo-L-tyrosine, which is reversed at concentrations greater than 5 microM Bos taurus 3-iodo-L-tyrosine + ? + I-
-
 ?
3,5-diiodo-L-tyrosine + NADPH + H+ solubilized enzyme preparations are active with dithionite, but not with NADPH. Particle-bound enzyme uses both dithionite and NADPH. At concentrations of substrate below 1 microM, 3,5-diiodo-L-tyrosine is more rapidly deiodinated than 3-iodo-L-tyrosine, which is reversed at concentrations greater than 5 microM Bos taurus 3-iodo-L-tyrosine + NADP+ + I-
-
 ?