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Literature summary for 1.20.99.1 extracted from

  • Bennett, M.S.; Guan, Z.; Laurberg, M.; Su, X.D.
    Bacillus subtilis arsenate reductase is structurally and functionally similar to low molecular weight protein tyrosine phosphatases (2001), Proc. Natl. Acad. Sci. USA, 98, 13577-13582.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
purified wild-type and selenomethionine-labeled enzyme, hanging drop vapour diffusion method, enzyme in 0.1 M sodium acetate, pH 4.4-4.6, 0.2 M ammonium sulfate, in presence of 30-35% PEG methyl ether, and 5 mM DTT, crystal structure in reduced form, X-ray diffraction structure determination and analysis at 1.6-2.4 A resolution Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
arsenate + reduced acceptor Bacillus subtilis enzyme participates to achieve arsenate resistance to cells by reducing toxic arsenate to arsenite, arsenate is toxic due to its ability to mimic the phosphate group arsenite + acceptor
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?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
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gene arsC
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Reaction

Reaction Comment Organism Reaction ID
arsenite + acceptor + H2O = arsenate + reduced acceptor catalytic mechanism involves the essential residues C10, C82, C89, R16, and D105, triple cysteine redox relay reduction mechanism, active site structure Bacillus subtilis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arsenate + reduced acceptor
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Bacillus subtilis arsenite + acceptor
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?
arsenate + reduced acceptor enzyme participates to achieve arsenate resistance to cells by reducing toxic arsenate to arsenite, arsenate is toxic due to its ability to mimic the phosphate group Bacillus subtilis arsenite + acceptor
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?
additional information the enzyme also catalyzes the tyrosine phosphatase reaction in vitro dephosphorylizing e.g. 4-nitrophenyl phosphate Bacillus subtilis ?
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?

Synonyms

Synonyms Comment Organism
arsenate reductase
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Bacillus subtilis