Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.20.4.2 extracted from

  • Schmuck, E.M.; Board, P.G.; Whitbread, A.K.; Tetlow, N.; Cavanaugh, J.A.; Blackburn, A.C.; Masoumi, A.
    Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants: implications for arsenic metabolism and the age-at-onset of Alzheimers and Parkinsons diseases (2005), Pharmacogenet. Genomics, 15, 493-501.
    View publication on PubMed
Search for more literature for 1.20.4.2

Protein Variants

Protein Variants Comment Organism
A140D isoform GSTO2, natural polymorphism, no significant alteration in monomethylarsonate reductase activity Homo sapiens
DELTAE155 isoform GSTO2, natural polymorphism, 90% increase in monomethylarsonate reductase activity Homo sapiens
DELTAE155/E208K isoform GSTO2, natural polymorphism, 100% increase in monomethylarsonate reductase activity, decrease in heat stability Homo sapiens
E208K isoform GSTO2, natural polymorphism, slight increase in monomethylarsonate reductase activity, decrease in heat stability Homo sapiens
N142D isoform GSTO2, natural polymorphism, no significant alteration in monomethylarsonate reductase activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P78417 isoforms GSTO1, GSTO2 and their natural polymorphisms. Enzyme has additionally thioltransferase, dehydroascorbate reductase and dimethylarsonate reductase activities
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.27
-
 GSTO1 mutant A140D, 30°C, pH 5.5 Homo sapiens
0.33
-
 wild-type GSTO1, 30°C, pH 5.5 Homo sapiens
0.39
-
 GSTO1 mutant E208K, 30°C, pH 5.5 Homo sapiens
0.42
-
 wild-type GSTO1, 30°C, pH 5.5 Homo sapiens
0.44
-
 GSTO2 mutant N142D, 30°C, pH 5.5 Homo sapiens
0.65
-
 GSTO1 mutant DELTAE155, 30°C, pH 5.5 Homo sapiens
0.67
-
 GSTO1 mutant DELTAE155/E208K, 30°C, pH 5.5 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
monomethylarsonate + glutathione
-
 Homo sapiens monomethylarsonous acid + oxidized glutathione
-
 ?

Synonyms

Synonyms Comment Organism
GSTO1
-
 Homo sapiens
GSTO2
-
 Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
60
-
 wild-type, 30 min, 60% residual activity. GSTO1 mutant E208K, 30 min, 80% residual activity, GSTO1 mutant DELTAE155/E208K, 30 min, no residual activity Homo sapiens