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Literature summary for extracted from

  • Wu, B.; Song, J.; Beitz, E.
    Novel channel enzyme fusion proteins confer arsenate resistance (2010), J. Biol. Chem., 285, 40081-40087.
    View publication on PubMedView publication on EuropePMC


Organism UniProt Comment Textmining
Mycobacterium tuberculosis


Synonyms Comment Organism
arsenate reductase
Mycobacterium tuberculosis
ACR3-ArsC gene name, protein comprises two domains an aquaglyceroporin-derived N-terminal channel-like part fused to a C-terminal enzyme domain with similarity to ArsC arsenate reductase Mycobacterium tuberculosis

General Information

General Information Comment Organism
physiological function as a dual functional protein (arsenite channel and arsenate reductase) ACR3-ArsC rescues a yeast strain that is highly sensitive to arsenate due to deletion of the ACR2 reductase and all transport proteins for arsenite, ACR3, Fps1, and the vacuolar ABC transporter Ycf1 for arsenite-thiol conjugates Mycobacterium tuberculosis