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Literature summary for 1.2.7.4 extracted from

  • Dobbek, H.; Gremer, L.; Meyer, O.; Huber, R.
    Crystal structure and mechanism of CO dehydrogenase, a molybdo iron-sulfur flavoprotein containing S-selanylcysteine (1999), Proc. Natl. Acad. Sci. USA, 96, 8884-8889.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.7.4

Crystallization (Commentary)

Crystallization (Comment) Organism
vapor diffusion, 800 mM KH2PO4, 800 mM NaH2PO4, 2% 2-methyl-2,4-pentanediol, 100 mM HEPES, pH 7.3 Afipia carboxidovorans

Metals/Ions

Metals/Ions Comment Organism Structure
Molybdenum molybdopterin-cytosine dinucleotide cofactor is composed of a molybdenum ion with 2 oxo- and 1 hydroxoligand complexed by the enedithiolene group of molybdopterin Afipia carboxidovorans

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
17800
-
 L2,M2,S2, 2 * 17800 + 2 * 30200 + 2 * 88700, dimer of heterotrimers, SDS-PAGE, crystal structure Afipia carboxidovorans
30200
-
 L2,M2,S2, 2 * 17800 + 2 * 30200 + 2 * 88700, dimer of heterotrimers, SDS-PAGE, crystal structure Afipia carboxidovorans
88700
-
 L2,M2,S2, 2 * 17800 + 2 * 30200 + 2 * 88700, dimer of heterotrimers, SDS-PAGE, crystal structure Afipia carboxidovorans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CO + H2O + electron acceptor Afipia carboxidovorans a proton gradient across the cytoplasmic membrane is generated by channeling the electrons formed via cytochrome b561 into a CO-insensitive respiratory chain CO2 + reduced electron acceptor
-
 ?

Organism

Organism UniProt Comment Textmining
Afipia carboxidovorans
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CO + H2O + electron acceptor a proton gradient across the cytoplasmic membrane is generated by channeling the electrons formed via cytochrome b561 into a CO-insensitive respiratory chain Afipia carboxidovorans CO2 + reduced electron acceptor
-
 ?

Subunits

Subunits Comment Organism
hexamer L2,M2,S2, 2 * 17800 + 2 * 30200 + 2 * 88700, dimer of heterotrimers, SDS-PAGE, crystal structure Afipia carboxidovorans

Cofactor

Cofactor Comment Organism Structure
flavin adenine dinucleotide
-
 Afipia carboxidovorans
molybdopterin cytosine dinucleotide cofactor is buried at the center of the L subunit Afipia carboxidovorans