Inhibitors | Comment | Organism | Structure |
---|---|---|---|
nitazoxanide | 52% inhibition at 0.040 mM, 25°C, pH 7.4 | Clostridioides difficile | |
VPC161183 | 36% inhibition at 0.040 mM, 25°C, pH 7.4 | Clostridioides difficile | |
VPC161195 | 56% inhibition at 0.040 mM, 25°C, pH 7.4 | Clostridioides difficile | |
VPC161219 | 61% inhibition at 0.040 mM, 25°C, pH 7.4 | Clostridioides difficile | |
VPC162096 | - |
Clostridioides difficile | |
VPC162125 | 71% inhibition at 0.040 mM, 25°C, pH 7.4 | Clostridioides difficile | |
VPC162134 | 75% inhibition at 0.040 mM, 25°C, pH 7.4 | Clostridioides difficile | |
VPC16a1011 | 34% inhibition at 0.040 mM, 25°C, pH 7.4 | Clostridioides difficile | |
VPC16b1094 | 66% inhibition at 0.040 mM, 25°C, pH 7.4 | Clostridioides difficile | |
VPC16b2031 | 84% inhibition at 0.040 mM, 25°C, pH 7.4 | Clostridioides difficile |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pyruvate + CoA + oxidized ferredoxin | Clostridioides difficile | - |
acetyl-CoA + CO2 + reduced ferredoxin + H+ | - |
? | |
pyruvate + CoA + oxidized ferredoxin | Clostridioides difficile ATCC 43255 | - |
acetyl-CoA + CO2 + reduced ferredoxin + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Clostridioides difficile | - |
- |
- |
Clostridioides difficile ATCC 43255 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pyruvate + CoA + oxidized benzyl viologen | - |
Clostridioides difficile | acetyl-CoA + CO2 + reduced benzyl viologen + H+ | - |
? | |
pyruvate + CoA + oxidized benzyl viologen | - |
Clostridioides difficile ATCC 43255 | acetyl-CoA + CO2 + reduced benzyl viologen + H+ | - |
? | |
pyruvate + CoA + oxidized ferredoxin | - |
Clostridioides difficile | acetyl-CoA + CO2 + reduced ferredoxin + H+ | - |
? | |
pyruvate + CoA + oxidized ferredoxin | - |
Clostridioides difficile ATCC 43255 | acetyl-CoA + CO2 + reduced ferredoxin + H+ | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.008 | - |
25°C, pH 7.4 | Clostridioides difficile | VPC162134 | |
0.024 | - |
25°C, pH 7.4 | Clostridioides difficile | nitazoxanide |