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Literature summary for 1.2.7.1 extracted from

  • Leitsch, D.; Burgess, A.G.; Dunn, L.A.; Krauer, K.G.; Tan, K.; Duchene, M.; Upcroft, P.; Eckmann, L.; Upcroft, J.A.
    Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia (2011), J. Antimicrob. Chemother., 66, 1756-1765.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyruvate + CoA + oxidized ferredoxin Giardia intestinalis
-
acetyl-CoA + CO2 + reduced ferredoxin + H+
-
?

Organism

Organism UniProt Comment Textmining
Giardia intestinalis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
DE52 column chromatography, DEAE-cellulose column chromatography, and Sephadex G25 gel filtration Giardia intestinalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate + CoA + oxidized ferredoxin
-
Giardia intestinalis acetyl-CoA + CO2 + reduced ferredoxin + H+
-
?

Synonyms

Synonyms Comment Organism
PFOR
-
Giardia intestinalis
pyruvate:ferredoxin oxidoreductase
-
Giardia intestinalis

General Information

General Information Comment Organism
malfunction resistance to metronidazole is associated with enzyme down-regulation Giardia intestinalis