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Literature summary for 1.2.4.4 extracted from
- Regulation of mammalian pyruvate and branched-chain alpha-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation (1985), Curr. Top. Cell. Regul., 27, 41-49.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| thiamine diphosphate | - |
Bos taurus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | inner membrane matrix compartment | Bos taurus | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| additional information | - |
the MW of the multienzyme complex of bovine kidney is 3200000 Da | Bos taurus |
| additional information | - |
MW of the multienzyme complex of bovine heart is 8500000 Da | Bos taurus |
| 35000 | - |
alpha2,beta2, 2 * 46000 + 2 * 35000, enzyme from kidney, SDS-PAGE | Bos taurus |
| 36000 | - |
alpha2,beta2, 2 * 41000 + 2 * 36000, heart enzyme, SDS-PAGE | Bos taurus |
| 41000 | - |
alpha2,beta2, 2 * 41000 + 2 * 36000, heart enzyme, SDS-PAGE | Bos taurus |
| 46000 | - |
alpha2,beta2, 2 * 46000 + 2 * 35000, enzyme from kidney, SDS-PAGE | Bos taurus |
| 154000 | - |
E1, heart | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Bos taurus | regulation of the enzyme complex by phosphorylation and dephosphorylation | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Bos taurus | - |
| kidney | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | regulation of the enzyme complex by phosphorylation and dephosphorylation | Bos taurus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | the multienzyme complex from bovine heart contains 4 times E1, 60 times E2 and 2 times E3 | Bos taurus |
| tetramer | alpha2,beta2, 2 * 46000 + 2 * 35000, enzyme from kidney, SDS-PAGE | Bos taurus |
| tetramer | alpha2,beta2, 2 * 41000 + 2 * 36000, heart enzyme, SDS-PAGE | Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| CoA | - |
Bos taurus | |
| NAD+ | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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