Literature summary for 1.2.4.2 extracted from

McMillan, P.J.; Stimmler, L.M.; Foth, B.J.; McFadden, G.I.; Mueller, S.
The human malaria parasite Plasmodium falciparum possesses two distinct dihydrolipoamide dehydrogenases (2005), Mol. Microbiol., 55, 27-38.

Search for more literature for 1.2.4.2

Cloned(Commentary)

Cloned (Comment)	Organism
enzyme E1o is located on chromosome 8	Plasmodium falciparum

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	enzyme E1o contains mitochondrial targeting sequence	Plasmodium falciparum	5739	-
additional information	enzyme complex is expressed during erythrocytic stage of the parasite	Plasmodium falciparum	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine	Plasmodium falciparum	-	[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2	-	ir

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	enzyme E1o is a component of the alpha-ketoglutarate dehydrogenase multienzyme complex KGDH	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine	-	Plasmodium falciparum	[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2	-	ir

Synonyms

Synonyms	Comment	Organism
E1o	component of the alpha-ketoglutarate dehydrogenase multienzyme complex KGDH consisting of components E1o, EC 1.2.4.2, E2, EC 2.1.3.6, and E3, EC 1.8.1.4	Plasmodium falciparum

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Plasmodium falciparum
thiamine diphosphate	-	Plasmodium falciparum

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Release 2023.1 (January 2023)