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Literature summary for 1.2.4.2 extracted from
- Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species (2004), J. Neurosci., 24, 7779-7788.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ADP | activates the enzyme complex for production of reactive oxygen species in absence of NAD+ | Rattus norvegicus |  |
| carbonyl cyanide p-trifluoromethoxyphenylhydrazone | activates the enzyme complex for production of reactive oxygen species in absence of NAD+ | Rattus norvegicus | |
| rotenone | stimulates H2O2 production | Mus musculus | |
| rotenone | stimulates H2O2 production | Rattus norvegicus | |
| thiamine diphosphate | exogenous | Mus musculus | |
| thiamine diphosphate | exogenous | Rattus norvegicus | |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | knock-out mice, deficient in dihydrolipoyl dehydrogenase, show reduced 2-oxoglutarate dehydrogenase activity and reduced H2O2 production | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrial inner membrane | - |
Mus musculus | 5743 | - |
| mitochondrial inner membrane | - |
Rattus norvegicus | 5743 | - |
| mitochondrion | - |
Mus musculus | 5739 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Mus musculus | |
| Ca2+ | - |
Rattus norvegicus | |
| Mg2+ | - |
Mus musculus | |
| Mg2+ | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | Mus musculus | - |
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
ir | |
| 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | Rattus norvegicus | - |
[dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
ir | |
| additional information | Mus musculus | enzyme complex produces H2O2 in vivo, which is inhibited by NAD+ with the isolated enzyme complex and in mitochondria, physiological effects and regulation, overview | ? | - |
? | |
| additional information | Rattus norvegicus | enzyme complex produces H2O2 in vivo, which is inhibited by NAD+ with the isolated enzyme complex and in mitochondria, physiological effects and regulation, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
wild-type mice, and knock-out mice deficient in dihydrolipoyl dehydrogenase | - |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | - |
Mus musculus | [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
ir | |
| 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine | - |
Rattus norvegicus | [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 | - |
ir | |
| additional information | enzyme complex produces H2O2 in vivo, which is inhibited by NAD+ with the isolated enzyme complex and in mitochondria, physiological effects and regulation, overview | Mus musculus | ? | - |
? | |
| additional information | enzyme complex produces H2O2 in vivo, which is inhibited by NAD+ with the isolated enzyme complex and in mitochondria, physiological effects and regulation, overview | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alpha-ketoglutarate dehydrogenase multienzyme complex | - |
Mus musculus |
| alpha-ketoglutarate dehydrogenase multienzyme complex | - |
Rattus norvegicus |
| KGDHC | - |
Mus musculus |
| KGDHC | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at, H2O2 production | Mus musculus |
| 37 | - |
assay at, H2O2 production | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Mus musculus |
| 7.4 | - |
assay at | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Mus musculus | |
| NAD+ | - |
Rattus norvegicus | |
| thiamine diphosphate | - |
Mus musculus | |
| thiamine diphosphate | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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