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Literature summary for 1.2.4.1 extracted from

  • Qi, J.; Zhang, F.; Wang, Y.; Liu, T.; Tan, L.; Wang, S.; Tian, M.; Li, T.; Wang, X.; Ding, C.; Yu, S.
    Characterization of Mycoplasma gallisepticum pyruvate dehydrogenase alpha and beta subunits and their roles in cytoadherence (2018), PLoS ONE, 13, e0208745 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.4.1

Application

Application Comment Organism
medicine both subunits PDHA and PDHB are surface-exposed immunogenic proteins of Mycoplasma gallisepticum. The mouse anti-PDHA and anti-PDHB sera kill 48.0% and 75.1% of mycoplasmas, respectively. A combination of PDHA and PDHB antisera has a mean bactericidal rate of 65.2%. Both PDHA and PDHB adhere to DF-1 chicken embryo fibroblast cells and adherence is significantly inhibited by antisera against PDHA and PDHB. Both PDHA and PDHB are plasminogen-binding proteins Mycoplasma gallisepticum
synthesis when recombinant subunits PDHA and PDHB are mixed at a 1:1 molar ratio, they exhibit strong enzymatic activity. Alone, recombinant PDHA and PDHB exhibit no or weak enzymatic activity Mycoplasma gallisepticum

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Mycoplasma gallisepticum

Organism

Organism UniProt Comment Textmining
Mycoplasma gallisepticum Q7NAZ8 subunit PDHA
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Mycoplasma gallisepticum CVCC 1651 Q7NAZ8 subunit PDHA
-

Synonyms

Synonyms Comment Organism
AcoA
-
 Mycoplasma gallisepticum
PDHa
-
 Mycoplasma gallisepticum

General Information

General Information Comment Organism
physiological function both subunits PDHA and PDHB are surface-exposed immunogenic proteins of Mycoplasma gallisepticum. The mouse anti-PDHA and anti-PDHB sera kill 48.0% and 75.1% of mycoplasmas, respectively. A combination of PDHA and PDHB antisera has a mean bactericidal rate of 65.2%. Both PDHA and PDHB adhere to DF-1 chicken embryo fibroblast cells and adherence is significantly inhibited by antisera against PDHA and PDHB. Both PDHA and PDHB are plasminogen-binding proteins Mycoplasma gallisepticum