Literature summary for 1.2.4.1 extracted from

Peng, H.; Wang, T.; Xie, P.; Chen, T.; He, H.W.; Wan, J.
Molecular docking and three-dimensional quantitative structure-activity relationship studies on the binding modes of herbicidal 1-(substituted phenoxyacetoxy)alkylphosphonates to the E1 component of pyruvate dehydrogenase (2007), J. Agric. Food Chem., 55, 1871-1880.

Inhibitors

Inhibitors	Comment	Organism
(2-chlorophenyl)(dimethoxyphosphoryl)methyl [3-(trifluoromethyl)phenoxy]acetate	-	Escherichia coli
(3,4-dichlorophenyl)(dimethoxyphosphoryl)methyl [3-(trifluoromethyl)phenoxy]acetate	-	Escherichia coli
(3-chlorophenyl)(dimethoxyphosphoryl)methyl [3-(trifluoromethyl)phenoxy]acetate	-	Escherichia coli
(4-chlorophenyl)(dimethoxyphosphoryl)methyl [3-(trifluoromethyl)phenoxy]acetate	-	Escherichia coli
(dimethoxyphosphoryl)(4-methylphenyl)methyl [3-(trifluoromethyl)phenoxy]acetate	-	Escherichia coli
(dimethoxyphosphoryl)(phenyl)methyl (2,3-dichlorophenoxy)acetate	-	Escherichia coli
(dimethoxyphosphoryl)(phenyl)methyl (2,6-dichlorophenoxy)acetate	-	Escherichia coli
(dimethoxyphosphoryl)(phenyl)methyl (2-chloro-5-methylphenoxy)acetate	-	Escherichia coli
(dimethoxyphosphoryl)(phenyl)methyl (3-fluorophenoxy)acetate	-	Escherichia coli
(dimethoxyphosphoryl)(phenyl)methyl (4-chloro-2-methylphenoxy)acetate	-	Escherichia coli
(dimethoxyphosphoryl)(phenyl)methyl (4-chloro-3-methylphenoxy)acetate	-	Escherichia coli
(dimethoxyphosphoryl)(phenyl)methyl (4-chlorophenoxy)acetate	-	Escherichia coli
(dimethoxyphosphoryl)(phenyl)methyl (4-fluorophenoxy)acetate	-	Escherichia coli
1-(dimethoxyphosphoryl)ethyl (2,3-dichlorophenoxy)acetate	-	Escherichia coli
1-(dimethoxyphosphoryl)ethyl (2,6-dichlorophenoxy)acetate	-	Escherichia coli
1-(dimethoxyphosphoryl)ethyl (2-chloro-5-methylphenoxy)acetate	-	Escherichia coli
1-(dimethoxyphosphoryl)ethyl (3-fluorophenoxy)acetate	-	Escherichia coli
1-(dimethoxyphosphoryl)ethyl (4-chloro-2-methylphenoxy)acetate	-	Escherichia coli
1-(dimethoxyphosphoryl)ethyl (4-chloro-3-methylphenoxy)acetate	-	Escherichia coli
1-(dimethoxyphosphoryl)ethyl (4-chlorophenoxy)acetate	-	Escherichia coli
1-(dimethoxyphosphoryl)ethyl (4-fluorophenoxy)acetate	-	Escherichia coli
2,2,2-trichloro-1-(dimethoxyphosphoryl)ethyl (2,3-dichlorophenoxy)acetate	-	Escherichia coli
2,2,2-trichloro-1-(dimethoxyphosphoryl)ethyl (2-chloro-5-methylphenoxy)acetate	-	Escherichia coli
2,2,2-trichloro-1-(dimethoxyphosphoryl)ethyl (3-fluorophenoxy)acetate	-	Escherichia coli
2,2,2-trichloro-1-(dimethoxyphosphoryl)ethyl (4-chloro-2-methylphenoxy)acetate	-	Escherichia coli
2,2,2-trichloro-1-(dimethoxyphosphoryl)ethyl (4-chloro-3-methylphenoxy)acetate	-	Escherichia coli
2,2,2-trichloro-1-(dimethoxyphosphoryl)ethyl (4-chlorophenoxy)acetate	-	Escherichia coli
2,2,2-trichloro-1-(dimethoxyphosphoryl)ethyl (4-fluorophenoxy)acetate	-	Escherichia coli
O,O-dimethyl (2,3-dichlorophenoxyacetoxy)(furan-2-yl)-methylphosphonate	-	Escherichia coli
O,O-dimethyl (2,3-dichlorophenoxyacetoxy)(thien-2-yl)-methylphosphonate	-	Escherichia coli
O,O-dimethyl (2,4-dichlorophenoxyacetoxy)(furan-2-yl)-methylphosphonate	-	Escherichia coli
O,O-dimethyl (2,4-dichlorophenoxyacetoxy)(thien-2-yl)-methylphosphonate	-	Escherichia coli
O,O-dimethyl (2,6-dichlorophenoxyacetoxy)(furan-2-yl)-methylphosphonate	-	Escherichia coli
O,O-dimethyl (2,6-dichlorophenoxyacetoxy)(thien-2-yl)-methylphosphonate	-	Escherichia coli
O,O-dimethyl (2-chloro-5-methylphenoxyacetoxy)(furan-2-yl)methylphosphonate	-	Escherichia coli
O,O-dimethyl (2-chloro-5-methylphenoxyacetoxy)(thien-2-yl)methylphosphonate	-	Escherichia coli
O,O-dimethyl (3-fluorophenoxyacetoxy)(furan-2-yl)methylphosphonate	-	Escherichia coli
O,O-dimethyl (3-fluorophenoxyacetoxy)(thien-2-yl)methylphosphonate	-	Escherichia coli
O,O-dimethyl (4-chloro-2-methylphenoxyacetoxy)(furan-2-yl)methylphosphonate	-	Escherichia coli
O,O-dimethyl (4-chloro-2-methylphenoxyacetoxy)(thien-2-yl)methylphosphonate	-	Escherichia coli
O,O-dimethyl (4-chloro-3-methylphenoxyacetoxy)(furan-2-yl)methylphosphonate	-	Escherichia coli
O,O-dimethyl (4-chloro-3-methylphenoxyacetoxy)(thien-2-yl)methylphosphonate	-	Escherichia coli
O,O-dimethyl (4-chlorophenoxyacetoxy)(furan-2-yl)methylphosphonate	-	Escherichia coli
O,O-dimethyl (4-chlorophenoxyacetoxy)(thien-2-yl)methylphosphonate	-	Escherichia coli
O,O-dimethyl (4-fluorophenoxyacetoxy)(furan-2-yl)methylphosphonate	-	Escherichia coli
sodium methyl [[[(2,4-dichlorophenoxy)acetyl]oxy](2,4-dichlorophenyl)methyl]phosphonate	-	Escherichia coli
sodium methyl [[[(2,4-dichlorophenoxy)acetyl]oxy](3-nitrophenyl)methyl]phosphonate	-	Escherichia coli
sodium methyl [[[(2,4-dichlorophenoxy)acetyl]oxy](4-fluorophenyl)methyl]phosphonate	-	Escherichia coli
sodium methyl [[[(2,4-dichlorophenoxy)acetyl]oxy](4-methoxyphenyl)methyl]phosphonate	-	Escherichia coli
sodium methyl [[[(2,4-dichlorophenoxy)acetyl]oxy](phenyl)methyl]phosphonate	-	Escherichia coli
sodium o-methyl (2,4-dichlorophenoxyacetoxy)(2-chlorophenyl)methylphosphonate	-	Escherichia coli
sodium o-methyl (2,4-dichlorophenoxyacetoxy)(3,4-dichlorophenyl)methyl phosphonate	-	Escherichia coli
sodium o-methyl (2,4-dichlorophenoxyacetoxy)(4-chlorophenyl)methylphosphonate	-	Escherichia coli
sodium o-methyl (2,4-dichlorophenoxyacetoxy)(4-methylphenyl)methylphosphonate	-	Escherichia coli
sodium o-methyl (2,4-dichlorophenoxyacetoxy)(furan-2-yl)methylphosphonate	-	Escherichia coli
sodium o-methyl (2,4-dichlorophenoxyacetoxy)(pyridin-2-yl)methylphosphonate	-	Escherichia coli

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	activates	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P0AFG8	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pyruvate + CoA + NAD+	-	Escherichia coli	acetyl-CoA + CO2 + NADH	-	?

Synonyms

Synonyms	Comment	Organism
E1 component of pyruvate dehydrogenase	-	Escherichia coli
PDHc E1	-	Escherichia coli

Cofactor

Cofactor	Comment	Organism	Structure
thiamine diphosphate	-	Escherichia coli