Literature summary for 1.2.4.1 extracted from

Gurd, B.J.; Peters, S.J.; Heigenhauser, G.J.; LeBlanc, P.J.; Doherty, T.J.; Paterson, D.H.; Kowalchuk, J.M.
O2 uptake kinetics, pyruvate dehydrogenase activity, and muscle deoxygenation in young and older adults during the transition to moderate-intensity exercise (2008), Am. J. Physiol. Regul. Integr. Comp. Physiol., 294, R577-R584.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Homo sapiens	5739	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
muscle	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pyruvate + CoA + NAD+	-	Homo sapiens	acetyl-CoA + CO2 + NADH	-	?
pyruvate + lipoamide	-	Homo sapiens	S-acetyldihydrolipoamide + CO2	-	?

Synonyms

Synonyms	Comment	Organism
mitochondrial pyruvate dehydrogenase	-	Homo sapiens
PDH	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Homo sapiens
thiamine diphosphate	-	Homo sapiens

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Release 2023.1 (January 2023)