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Literature summary for 1.2.3.1 extracted from

  • Al-Omar, M.A.; Al-Rashood, S.T.; El-Subbagh, H.I.; Abdel Hamide, S.G.
    Interaction of 2-thio-4-oxo-quinazoline derivatives with guinea pig liver molybdenum hydroxylases, xanthine oxidase and aldehyde oxidase (2005), J. Biol. Sci., 5, 370-378.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
1-benzyl-3-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]thiourea comparison with inhibition of xanthine oxidase Cavia porcellus
2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-amine comparison with inhibition of xanthine oxidase Cavia porcellus
2-(methylthio)-6-nitro-3-phenyl-3,4-dihydroquinazoline comparison with inhibition of xanthine oxidase Cavia porcellus
3,4,5-trimethoxy-N-[2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-yl]benzamide comparison with inhibition of xanthine oxidase Cavia porcellus
3,4,5-trimethoxy-N-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]benzamide comparison with inhibition of xanthine oxidase Cavia porcellus
3,4-dimethoxy-N-[2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-yl]benzamide comparison with inhibition of xanthine oxidase Cavia porcellus
3,4-dimethoxy-N-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]benzamide comparison with inhibition of xanthine oxidase Cavia porcellus
3-benzyl-2-(methylthio)-3,4-dihydroquinazolin-6-amine comparison with inhibition of xanthine oxidase Cavia porcellus
3-benzyl-2-(methylthio)-6-nitro-3,4-dihydroquinazoline comparison with inhibition of xanthine oxidase Cavia porcellus
3-benzyl-6-nitro-3,4-dihydroquinazoline-2-thiol comparison with inhibition of xanthine oxidase Cavia porcellus
3-ethyl-2-(methylthio)-6-nitro-3,4-dihydroquinazoline comparison with inhibition of xanthine oxidase Cavia porcellus
3-ethyl-6-nitro-3,4-dihydroquinazoline-2-thiol comparison with inhibition of xanthine oxidase Cavia porcellus
4-bromo-N-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]benzenesulfonamide comparison with inhibition of xanthine oxidase Cavia porcellus
4-methoxy-N-[2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-yl]benzamide comparison with inhibition of xanthine oxidase Cavia porcellus
4-methoxy-N-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]benzamide comparison with inhibition of xanthine oxidase Cavia porcellus
4-methyl-N-[2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-yl]benzamide comparison with inhibition of xanthine oxidase Cavia porcellus
4-methyl-N-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]benzamide comparison with inhibition of xanthine oxidase Cavia porcellus
6-nitro-3-phenyl-3,4-dihydroquinazoline-2-thiol comparison with inhibition of xanthine oxidase Cavia porcellus
N-[(1E)-(3,4,5-trimethoxyphenyl)methylene]-2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-amine comparison with inhibition of xanthine oxidase Cavia porcellus
N-[(1E)-(3,4,5-trimethoxyphenyl)methylene]-2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-amine comparison with inhibition of xanthine oxidase Cavia porcellus
N-[(1E)-(3,4-dimethoxyphenyl)methylene]-2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-amine comparison with inhibition of xanthine oxidase Cavia porcellus
N-[(1E)-(3,4-dimethoxyphenyl)methylene]-2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-amine comparison with inhibition of xanthine oxidase Cavia porcellus
N-[(1E)-(4-methoxyphenyl)methylene]-2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-amine comparison with inhibition of xanthine oxidase Cavia porcellus
N-[(1E)-(4-methoxyphenyl)methylene]-2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-amine comparison with inhibition of xanthine oxidase Cavia porcellus
N-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]benzamide comparison with inhibition of xanthine oxidase Cavia porcellus

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver partially purified Cavia porcellus
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.103
-
6-nitro-3-phenyl-3,4-dihydroquinazoline-2-thiol 37°C Cavia porcellus
0.105
-
3-ethyl-6-nitro-3,4-dihydroquinazoline-2-thiol 37°C Cavia porcellus
0.109
-
3-benzyl-2-(methylthio)-6-nitro-3,4-dihydroquinazoline 37°C Cavia porcellus
0.113
-
2-(methylthio)-6-nitro-3-phenyl-3,4-dihydroquinazoline 37°C Cavia porcellus
0.136
-
3-benzyl-2-(methylthio)-3,4-dihydroquinazolin-6-amine 37°C Cavia porcellus
0.142
-
3-ethyl-2-(methylthio)-6-nitro-3,4-dihydroquinazoline 37°C Cavia porcellus
0.148
-
2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-amine 37°C Cavia porcellus
0.184
-
3-benzyl-6-nitro-3,4-dihydroquinazoline-2-thiol 37°C Cavia porcellus
0.295
-
N-[(1E)-(3,4-dimethoxyphenyl)methylene]-2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-amine 37°C Cavia porcellus
0.31
-
N-[(1E)-(4-methoxyphenyl)methylene]-2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-amine 37°C Cavia porcellus
0.31
-
N-[(1E)-(4-methoxyphenyl)methylene]-2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-amine 37°C Cavia porcellus
0.37
-
N-[(1E)-(3,4-dimethoxyphenyl)methylene]-2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-amine 37°C Cavia porcellus
0.4
-
N-[(1E)-(3,4,5-trimethoxyphenyl)methylene]-2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-amine 37°C Cavia porcellus
0.425
-
3,4,5-trimethoxy-N-[2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-yl]benzamide 37°C Cavia porcellus
0.43
-
3,4,5-trimethoxy-N-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]benzamide 37°C Cavia porcellus
0.435
-
N-[(1E)-(3,4,5-trimethoxyphenyl)methylene]-2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-amine 37°C Cavia porcellus
0.445
-
4-methoxy-N-[2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-yl]benzamide 37°C Cavia porcellus
0.45
-
4-methoxy-N-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]benzamide 37°C Cavia porcellus
0.46
-
4-methyl-N-[2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-yl]benzamide 37°C Cavia porcellus
0.505
-
N-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]benzamide 37°C Cavia porcellus
0.505
-
4-methyl-N-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]benzamide 37°C Cavia porcellus
0.51
-
3,4-dimethoxy-N-[2-(methylthio)-3-benzyl-3,4-dihydroquinazolin-6-yl]benzamide 37°C Cavia porcellus
0.52
-
4-bromo-N-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]benzenesulfonamide 37°C Cavia porcellus
0.53
-
1-benzyl-3-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]thiourea 37°C Cavia porcellus
0.55
-
3,4-dimethoxy-N-[2-(methylthio)-3-phenyl-3,4-dihydroquinazolin-6-yl]benzamide 37°C Cavia porcellus