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Literature summary for 1.2.3.1 extracted from
- Properties of retinal-oxidizing enzyme activity in rat kidney (1988), Biochim. Biophys. Acta, 967, 211-217.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-Aminobenzaldehyde | complete inhibition at 5 mM, partially reversed by retinal | Rattus sp. |  |
| 4'-(9-acridinylamino)methanesulfonaniside | dose-dependent inhibition, no complete inhibition | Rattus sp. | |
| acetaldehyde | 77% inhibition at 5 mM, partially reversed by retinal | Rattus sp. | |
| hydroxytoluene | butylated, 50% inhibition at 1 mM | Rattus sp. | |
| p-hydroxymercuribenzoate | complete inhibition at 3 mM, reversed by DTT | Rattus sp. | |
| propyl 3,4,5-trihydroxybenzoate | 91% inhibition at 3 mM | Rattus sp. | |
| Quinacrine | 76% inhibition at 1 mM, partially reversed by FAD | Rattus sp. | |
| retinol | complete inhibition at 0.5 mM | Rattus sp. | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Rattus sp. | 5737 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| all-trans-retinal + O2 + H2O | Rattus sp. | - |
all-trans-retinoate + H2O2 | - |
? | |
| retinal + O2 + H2O | Rattus sp. | activity is dependent on vitamin A levels of tissues | retinoate + H2O2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus sp. | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus sp. | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70°C, stable for 6 months | Rattus sp. |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| all-trans-retinal + O2 + H2O | - |
Rattus sp. | all-trans-retinoate + H2O2 | - |
? | |
| retinal + O2 + H2O | activity is dependent on vitamin A levels of tissues | Rattus sp. | retinoate + H2O2 | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
- |
Rattus sp. |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Rattus sp. |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Rattus sp. | |
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