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Literature summary for 1.2.3.1 extracted from

  • Tomita, S.; Tsujita, M.; Ichikawa, Y.
    Retinal oxidase is identical to aldehyde oxidase (1993), FEBS Lett., 336, 272-274.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
N-methylnicotinamide competitive inhibition Oryctolagus cuniculus
superoxid dismutase complete inhibition at 0.001 mM Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.008
-
all-trans-retinal
-
Oryctolagus cuniculus
0.013
-
9-cis retinal
-
Oryctolagus cuniculus
0.22
-
purine
-
Oryctolagus cuniculus
0.9
-
13-cis retinal
-
Oryctolagus cuniculus
1.4
-
hypoxanthine
-
Oryctolagus cuniculus
1.7
-
xanthine
-
Oryctolagus cuniculus
7
-
N-methylnicotinamide
-
Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Oryctolagus cuniculus 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe 8.24 mol per mol enzyme Oryctolagus cuniculus
Mo 2.01 mol per mol enzyme Oryctolagus cuniculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
135000
-
2 * 135000, SDS-PAGE Oryctolagus cuniculus
270000
-
gel filtration Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
13-cis-retinal + O2 + H2O Oryctolagus cuniculus
-
13-cis-retinoate + H2O2
-
?
4-hydroxypyrazolo(3,4-d)pyrimidine + O2 + H2O Oryctolagus cuniculus 12-13% of the activity compared to purine 4,6-dihydroxypyrazolo(3,4-d)pyrimidine + H2O2
-
?
4-hydroxypyrazolo(3,4-d)pyrimidine + O2 + H2O Oryctolagus cuniculus i.e. allopurinol 4,6-dihydroxypyrazolo(3,4-d)pyrimidine + H2O2
-
?
9-cis-retinal + O2 + H2O Oryctolagus cuniculus
-
9-cis-retinoate + H2O2
-
?
all-trans-retinal + O2 + H2O Oryctolagus cuniculus
-
all-trans-retinoate + H2O2
-
?
hypoxanthine + O2 + H2O Oryctolagus cuniculus 22-26% of the activity compared to purine xanthine + H2O2
-
?
purine + O2 + H2O Oryctolagus cuniculus best substrate tested ? + H2O2
-
?
xanthine + O2 + H2O Oryctolagus cuniculus low activity urate + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
rabbit
-

Purification (Commentary)

Purification (Comment) Organism
-
Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
13-cis-retinal + O2 + H2O
-
Oryctolagus cuniculus 13-cis-retinoate + H2O2
-
?
2-hydroxypyrimidine + O2 + H2O
-
Oryctolagus cuniculus ? + H2O2
-
?
4-hydroxypyrazolo(3,4-d)pyrimidine + O2 + H2O 12-13% of the activity compared to purine Oryctolagus cuniculus 4,6-dihydroxypyrazolo(3,4-d)pyrimidine + H2O2
-
?
4-hydroxypyrazolo(3,4-d)pyrimidine + O2 + H2O i.e. allopurinol Oryctolagus cuniculus 4,6-dihydroxypyrazolo(3,4-d)pyrimidine + H2O2
-
?
9-cis-retinal + O2 + H2O
-
Oryctolagus cuniculus 9-cis-retinoate + H2O2
-
?
all-trans-retinal + O2 + H2O
-
Oryctolagus cuniculus all-trans-retinoate + H2O2
-
?
hypoxanthine + O2 + H2O 22-26% of the activity compared to purine Oryctolagus cuniculus xanthine + H2O2
-
?
N-methylnicotinamide + electron acceptor + H2O electron acceptors i.e.: dichlorophenolindophenol, nitro blue tetrazolium, ferricyanide, diaphorase activity Oryctolagus cuniculus ?
-
?
purine + O2 + H2O best substrate tested Oryctolagus cuniculus ? + H2O2
-
?
xanthine + O2 + H2O low activity Oryctolagus cuniculus urate + H2O2
-
?

Subunits

Subunits Comment Organism
dimer 2 * 135000, SDS-PAGE Oryctolagus cuniculus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.447
-
N-methylnicotinamide electron acceptor: cytochrome c Oryctolagus cuniculus
1.14
-
N-methylnicotinamide electron acceptor: nitro blue tetrazolium Oryctolagus cuniculus
1.81
-
N-methylnicotinamide electron acceptor: dichlorophenolinodphenol Oryctolagus cuniculus
1.97
-
N-methylnicotinamide electron acceptor: ferricyanide Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
FAD 2.0 mol FAD per mol enzyme Oryctolagus cuniculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1
-
N-methylnicotinamide
-
Oryctolagus cuniculus