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Literature summary for 1.2.3.1 extracted from

  • Sugihara, K.; Katsuma, Y.; Tanaka, C.; Kitamura, S.
    Purification and some properties of hamster liver aldehyde oxidase (1999), Biol. Pharm. Bull., 22, 1246-1248.
    View publication on PubMed
Search for more literature for 1.2.3.1

Inhibitors

Inhibitors Comment Organism Structure
chlorpromazine
-
 Cavia porcellus
chlorpromazine 94% inhibition at 0.1 mM Mesocricetus auratus
CuSO4 85% inhibition at 0.1 mM Mesocricetus auratus
dicoumarol
-
 Cavia porcellus
dicoumarol 43% inhibition at 0.1 mM Mesocricetus auratus
KCN
-
 Cavia porcellus
KCN 95% inhibition at 1 mM Mesocricetus auratus
KCN
-
 Oryctolagus cuniculus
menadione
-
 Cavia porcellus
menadione 91.5% inhibition at 0.01 mM Mesocricetus auratus
menadione
-
 Oryctolagus cuniculus
p-chloromercuribenzoic acid
-
 Cavia porcellus
p-chloromercuribenzoic acid 96% inhibition at 0.1 mM Mesocricetus auratus
Quinacrine 74% inhibition at 0.1 mM Mesocricetus auratus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0044
-
 2-hydroxypyrimidine
-
 Mesocricetus auratus
0.019
-
 benzaldehyde
-
 Mesocricetus auratus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Cavia porcellus 5829
-
cytosol
-
 Oryctolagus cuniculus 5829
-
cytosol
-
 Mesocricetus auratus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+
-
 Cavia porcellus
Fe2+
-
 Oryctolagus cuniculus
Fe2+
-
 Mesocricetus auratus
Mo5+
-
 Cavia porcellus
Mo5+
-
 Oryctolagus cuniculus
Mo5+
-
 Mesocricetus auratus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
144800
-
 alpha2, 2 * 144800, SDS-PAGE Mesocricetus auratus
288000
-
 gel filtration Mesocricetus auratus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mesocricetus auratus enzyme plays an important role in detoxification of the toxic heterocycles synthesized by certain plants ?
-
 ?

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-
Mesocricetus auratus
-
-
-
Oryctolagus cuniculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mesocricetus auratus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Cavia porcellus
-
liver
-
 Oryctolagus cuniculus
-
liver
-
 Mesocricetus auratus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.77
-
-
 Mesocricetus auratus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-hydroxypyrimidine + H2O + O2
-
 Cavia porcellus uracil + H2O2
-
 ?
2-hydroxypyrimidine + H2O + O2
-
 Oryctolagus cuniculus uracil + H2O2
-
 ?
2-hydroxypyrimidine + H2O + O2
-
 Mesocricetus auratus uracil + H2O2
-
 ?
benzaldehyde + H2O + O2
-
 Cavia porcellus benzoic acid + H2O2
-
 ?
benzaldehyde + H2O + O2
-
 Oryctolagus cuniculus benzoic acid + H2O2
-
 ?
benzaldehyde + H2O + O2
-
 Mesocricetus auratus benzoic acid + H2O2
-
 ?
additional information enzyme plays an important role in detoxification of the toxic heterocycles synthesized by certain plants Mesocricetus auratus ?
-
 ?
N1-methylnicotinamide + H2O + O2
-
 Cavia porcellus N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
 ?
N1-methylnicotinamide + H2O + O2
-
 Oryctolagus cuniculus N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
 ?
N1-methylnicotinamide + H2O + O2
-
 Mesocricetus auratus N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
 ?

Subunits

Subunits Comment Organism
dimer alpha2, 2 * 144800, SDS-PAGE Mesocricetus auratus

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Cavia porcellus
FAD
-
 Oryctolagus cuniculus
FAD
-
 Mesocricetus auratus