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Literature summary for 1.2.3.1 extracted from

  • Al-Salmy, H.S.
    Individual variation in hepatic aldehyde oxidase activity (2001), IUBMB Life, 51, 249-253.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
menadione
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.004 0.015 benzaldehyde
-
Homo sapiens
0.008 0.014 N-[(2-dimethylamino)ethyl] acridine-4-carboxamide
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ 2 Fe/S iron centres Homo sapiens
Mo5+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-fluoropyrimidine + H2O + O2
-
Homo sapiens 5-fluorouracil + H2O2
-
?
benzaldehyde + H2O + O2
-
Homo sapiens benzoic acid + H2O2
-
?
additional information enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine Homo sapiens ?
-
?
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide + H2O + O2
-
Homo sapiens N-[(2-dimethylamino)ethyl] acridine-4-carboxamide-9(10H)-acridone + H2O2
-
?

Synonyms

Synonyms Comment Organism
AO
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
benzaldehyde assay at Homo sapiens
37
-
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide assay Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0003 0.0086 menadione
-
Homo sapiens