Literature summary for 1.2.1.95 extracted from

Guo, S.; Bhattacharjee, J.K.
Posttranslational activation, site-directed mutation and phylogenetic analyses of the lysine biosynthesis enzymes alpha-aminoadipate reductase Lys1p (AAR) and the phosphopantetheinyl transferase Lys7p (PPTase) from Schizosaccharomyces pombe (2004), Yeast, 21, 1279-1288.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Schizosaccharomyces pombe

Protein Variants

Protein Variants	Comment	Organism
G910A	mutation in the activation domain (IGGHSI), no activity	Schizosaccharomyces pombe
additional information	enzyme Lys1 is active when expressed in Escherichia coli and exhibits significant alpha-aminoadipate reductase activity without the addition of CoA or Schizosaccharomyces pombe phosphopantetheinyl transferase	Schizosaccharomyces pombe
S913A	mutation in the activation domain (IGGHSI), no activity	Schizosaccharomyces pombe
S913T	mutation in the activation domain (IGGHSI), no activity	Schizosaccharomyces pombe

Organism

Organism	UniProt	Comment	Textmining
Schizosaccharomyces pombe	P40976	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
side-chain modification	enzyme Lys1 is active when expressed in Escherichia coli and exhibits significant alpha-aminoadipate reductase activity without the addition of CoA or Schizosaccharomyces pombe phosphopantetheinyl transferase	Schizosaccharomyces pombe

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Release 2023.1 (January 2023)