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Literature summary for 1.2.1.95 extracted from

  • Guo, S.; Evans, S.A.; Wilkes, M.B.; Bhattacharjee, J.K.
    Novel posttranslational activation of the LYS2-encoded.alpha-aminoadipate reductase for biosynthesis of lysine and site-directed mutational analysis of conserved amino acid residues in the activation domain of Candida albicans (2001), J. Bacteriol., 183, 7120-7125.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Candida albicans

Protein Variants

Protein Variants Comment Organism
G881E conserved residue in the posttranslational activation domain LGGHSI, less than 50% of wild-type activity Candida albicans
G882R conserved residue in the posttranslational activation domain LGGHSI, loss of activity Candida albicans
G882S conserved residue in the posttranslational activation domain LGGHSI, loss of activity Candida albicans
H883R conserved residue in the posttranslational activation domain LGGHSI, strong reduction of activity Candida albicans
I885L G881E conserved residue in the posttranslational activation domain LGGHSI, less than 50% of wild-type activity Candida albicans
S884A conserved residue in the posttranslational activation domain LGGHSI, loss of activity Candida albicans
S884F conserved residue in the posttranslational activation domain LGGHSI, loss of activity Candida albicans

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
150000
-
 x * 150000, SDS-PAGE Candida albicans

Organism

Organism UniProt Comment Textmining
Candida albicans Q12572
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification alpha-aminoadipate reductase Lys2 is posttranslationally activated by phosphopantetheinyl transferase Lys5 which transfers a phosphopantetheinyl group from coenzyme A to Lys2. Activation is required for catalytic activity Candida albicans

Subunits

Subunits Comment Organism
? x * 150000, SDS-PAGE Candida albicans

Synonyms

Synonyms Comment Organism
LYS2
-
 Candida albicans