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Literature summary for 1.2.1.88 extracted from

  • Ion, B.; Aboelnga, M.; Gauld, J.
    Insights from molecular dynamics on substrate binding and effects of active site mutations in delta1-pyrroline-5-carboxylate dehydrogenase (2016), Can. J. Chem., 94, 1151-1162.
No PubMed abstract available

Protein Variants

Protein Variants Comment Organism
E314A inactive. The conserved Glu447 residue has significantly shifted in the mutant, causing NAD+ to be displaced Homo sapiens
S352A catalytic site including the oxoanion hole and residue Cys348 remain unchanged in the mutant, and the coenzyme maintains its binding position Homo sapiens
S352L inactive. The conserved Glu447 residue has significantly shifted in the mutant, causing NAD+ to be displaced Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P30038
-
-

Synonyms

Synonyms Comment Organism
P5CDH
-
Homo sapiens