Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
expression in Escherichia coli | Saccharomyces cerevisiae |
Crystallization (Comment) | Organism |
---|---|
apoenzyme and in complex with NAD+, to 1.95 and 2.17 A resolution, respectively | Saccharomyces cerevisiae |
the substrate-free form displays multiple active site conformations. Protein forms a trimer-of-dimers hexamer in solution | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
W193A | mutation disrupts hexamer formation, mutant forms a dimer | Saccharomyces cerevisiae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.104 | - |
1-pyrroline-5-carboxylate | pH 7.5, 20°C | Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P30038 | - |
- |
Saccharomyces cerevisiae | P07275 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-pyrroline-5-carboxylate + NADH + H+ | - |
Saccharomyces cerevisiae | L-proline + NAD+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
hexamer | crystallization data | Saccharomyces cerevisiae |
Synonyms | Comment | Organism |
---|---|---|
Aldh4a1 | - |
Homo sapiens |
Aldh4a1 | - |
Saccharomyces cerevisiae |
Put2 | - |
Saccharomyces cerevisiae |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.5 | - |
1-pyrroline-5-carboxylate | pH 7.5, 20°C | Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Saccharomyces cerevisiae |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
14 | - |
1-pyrroline-5-carboxylate | pH 7.5, 20°C | Saccharomyces cerevisiae |