Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-aminobutyrate | both isoforms | Hyalomma dromedarii | |
ADP | 3 mM, 14% inhibition of isoform A and 16% inhibition of isoform B | Hyalomma dromedarii | |
AMP | 3 mM, 33% inhibition of isoform A and 11% inhibition of isoform B | Hyalomma dromedarii | |
arsenite | both isoforms | Hyalomma dromedarii | |
ATP | inhibits isoform B by 33%, but not isoform A | Hyalomma dromedarii | |
Co2+ | both isoforms, concentration above 3 mM | Hyalomma dromedarii | |
Gly | - |
Hyalomma dromedarii | |
Hg2+ | both isoforms | Hyalomma dromedarii | |
iodoacetamide | both isoforms | Hyalomma dromedarii | |
L-Ala | - |
Hyalomma dromedarii | |
L-Glu | - |
Hyalomma dromedarii | |
L-hydroxyproline | both isoforms, potent inhibition | Hyalomma dromedarii | |
L-Leu | - |
Hyalomma dromedarii | |
L-Ser | - |
Hyalomma dromedarii | |
L-Val | - |
Hyalomma dromedarii | |
Ni2+ | both isoforms | Hyalomma dromedarii | |
p-hydroxymercuribenzoate | both isoforms, potent inhibition | Hyalomma dromedarii | |
proline | both isoforms | Hyalomma dromedarii | |
Zn2+ | both isoforms | Hyalomma dromedarii |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.133 | - |
D-glucose | isoform A | Hyalomma dromedarii | |
0.2 | - |
1-pyrroline-5-carboxylate | isoform B, with NADP+ | Hyalomma dromedarii | |
0.2 | - |
indol-3-acetaldehyde | isoform A | Hyalomma dromedarii | |
0.25 | - |
4-methoxybenzaldehyde | isoform A | Hyalomma dromedarii | |
0.27 | - |
p-nitrobenzaldehyde | isoform A | Hyalomma dromedarii | |
0.3 | - |
1-pyrroline-5-carboxylate | isoform B, with NAD+ | Hyalomma dromedarii | |
0.3 | - |
1-pyrroline-5-carboxylate | isoform A, with NADP+ | Hyalomma dromedarii | |
0.33 | - |
1-pyrroline-5-carboxylate | isoform A, with NAD+ | Hyalomma dromedarii | |
0.5 | - |
benzaldehyde | isoform A | Hyalomma dromedarii | |
0.5 | - |
3-Methoxybenzaldehyde | isoform A | Hyalomma dromedarii | |
0.62 | - |
NAD+ | isoform A | Hyalomma dromedarii | |
0.76 | - |
formaldehyde | isoform A | Hyalomma dromedarii | |
1 | - |
NADP+ | isoform A | Hyalomma dromedarii | |
1 | - |
acetaldehyde | isoform A | Hyalomma dromedarii | |
1 | - |
glyoxylic acid | isoform A | Hyalomma dromedarii |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
isoform B, gel filtration | Hyalomma dromedarii |
52000 | - |
1 * 52000, isoform B, SDS-PAGE | Hyalomma dromedarii |
59000 | - |
1 * 59000, isoform A, SDS-PAGE | Hyalomma dromedarii |
60000 | - |
isoform A, gel filtration | Hyalomma dromedarii |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hyalomma dromedarii | - |
two isoforms A and B | - |
Hyalomma dromedarii | - |
camel tick | - |
Purification (Comment) | Organism |
---|---|
amino acid composition determination | Hyalomma dromedarii |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Hyalomma dromedarii | - |
larva | - |
Hyalomma dromedarii | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.151 | - |
embryo, 24 days after oviposition | Hyalomma dromedarii |
0.223 | - |
larvae | Hyalomma dromedarii |
9.75 | - |
purified enzyme | Hyalomma dromedarii |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-pyrroline-5-carboxylate + NAD+ + H2O | - |
Hyalomma dromedarii | L-glutamate + NADH | - |
? | |
1-pyrroline-5-carboxylate + NADP+ + H2O | - |
Hyalomma dromedarii | L-glutamate + NADPH + H+ | - |
r | |
3-methoxybenzaldehyde + NAD+ + H2O | as active as 1-pyrroline-5-carboxylate with isoform A, no activity with isoform B | Hyalomma dromedarii | 3-methoxybenzoate + NADH | - |
? | |
4-methoxybenzaldehyde + NAD+ + H2O | as active as 1-pyrroline-5-carboxylate with isoform A, no activity with isoform B | Hyalomma dromedarii | 4-methoxybenzoate + NADH + H+ | - |
? | |
4-nitrobenzaldehyde + NAD+ + H2O | as active as 1-pyrroline-5-carboxylate with isoform A, only slight activity with isoform B | Hyalomma dromedarii | 4-nitrobenzoate + NADH + H+ | - |
? | |
acetaldehyde + NAD+ + H2O | 41% activity compared to 1-pyrroline-5-carboxylate with isoform A, only slight activity with isoform B | Hyalomma dromedarii | acetate + NADH + H+ | - |
? | |
benzaldehyde + NAD+ + H2O | 2fold higher activity than with 1-pyrroline-5-carboxylate, isoform A, only slight activity with isoform B | Hyalomma dromedarii | benzoate + NADH + H+ | - |
? | |
D-glucose + NAD+ + H2O | 80% of the activity with 1-pyrroline-5-carboxylate with isoform A, no activity with isoform B | Hyalomma dromedarii | D-gluconate + NADH | - |
? | |
formaldehyde + NAD+ + H2O | 50% of activity with 1-pyrroline-5-carboxylate, isoform A, only slight activity with isoform B | Hyalomma dromedarii | formate + NADH | - |
? | |
glyceralaldehyde-3-phosphate + NAD+ + H2O | slight activity with isoforms A and B | Hyalomma dromedarii | glycerate-3-phosphate + NADH | - |
? | |
glyoxylic acid + NAD+ + H2O | 41% activity of that with 1-pyrroline-5-carboxylate with isoform A, no activity with isoform B | Hyalomma dromedarii | oxalic acid + NADH | - |
? | |
indole-3-acetaldehyde + NAD+ + H2O | 66% activity of that with 1-pyrroline-5-carboxylate with isoform A, only slight activity with isoform B | Hyalomma dromedarii | indole-3-acetate + NADH + H+ | - |
? | |
indole-3-phosphate + NAD+ + H2O | slight activity with isoforms A and B | Hyalomma dromedarii | ? | - |
? | |
additional information | additional esterase activity with p-nitrophenyl acetate as substrate, 50% of activity with 1-pyrroline-5-carboxylate, isoform A, only slight activity with isoform B | Hyalomma dromedarii | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 59000, isoform A, SDS-PAGE | Hyalomma dromedarii |
monomer | 1 * 52000, isoform B, SDS-PAGE | Hyalomma dromedarii |
Synonyms | Comment | Organism |
---|---|---|
P5CD | - |
Hyalomma dromedarii |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
both isoforms | Hyalomma dromedarii |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
2.5 | - |
proline | isoform B | Hyalomma dromedarii | |
3 | - |
gamma-aminobutyrate | isoform B | Hyalomma dromedarii | |
3 | - |
proline | isoform A | Hyalomma dromedarii | |
3.4 | - |
glutamate | isoform B | Hyalomma dromedarii | |
3.75 | - |
hydroxyproline | isoform B | Hyalomma dromedarii | |
3.75 | - |
gamma-aminobutyrate | isoform A | Hyalomma dromedarii | |
4.75 | - |
hydroxyproline | isoform A | Hyalomma dromedarii | |
7 | - |
glutamate | isoform A | Hyalomma dromedarii |