Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.2.1.82 extracted from

  • Estrada, A.F.; Maier, D.; Scherzinger, D.; Avalos, J.; Al-Babili, S.
    Novel apocarotenoid intermediates in Neurospora crassa mutants imply a new biosynthetic reaction sequence leading to neurosporaxanthin formation (2008), Fungal Genet. Biol., 45, 1497-1505.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Neurospora crassa Q1K615
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
apo-4'-lycopenal + NAD+ + H2O the in vivo substrate of Ylo-1 is apo-4'-lycopenal rather than its cyclic isomer beta-apo-4'-carotenal Neurospora crassa apo-4'-lycopenoic acid + NADH + 2 H+
-
?

Synonyms

Synonyms Comment Organism
YLO-1
-
Neurospora crassa

General Information

General Information Comment Organism
physiological function enzyme is involved in the biosynthetic pathway to neurosporaxanthin. First step is the cleavage of 3,4-didehydrolycopene into apo-4'-lycopenal by Cao2, which is then oxidized by YLO-1 to yield apo-4'-lycopenoic acid, the last intermediate in the pathway. The final step is then catalyzed by the cyclase activity of AL-2. An Ylo-1 mutant accumulates three major pigments, i.e. lycopene, apo-4'-lycopenal and apo-4'-lycopenol. The pigments accumulating in the Ylo-1 mutant are non-cyclic and represent lycopene and apolycopenoids, indicating that the in vivo substrate of Ylo-1 is apo-4'-lycopenal rather than its cyclic isomer beta-apo-4'-carotenal Neurospora crassa