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Literature summary for 1.2.1.8 extracted from

  • Lee, J.J.; Kim, J.H.; Kim, D.G.; Kim, D.H.; Simborio, H.L.; Min, W.G.; Rhee, M.H.; Lim, J.H.; Chang, H.H.; Kim, S.
    Characterization of betaine aldehyde dehydrogenase (BetB) as an essential virulence factor of Brucella abortus (2014), Vet. Microbiol., 168, 131-140.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
betaine aldehyde + NAD+ + H2O Brucella abortus
-
betaine + NADH + H+
-
?
betaine aldehyde + NAD+ + H2O Brucella abortus 9-941
-
betaine + NADH + H+
-
?
betaine aldehyde + NADP+ + H2O Brucella abortus
-
betaine + NADPH + H+
-
?
betaine aldehyde + NADP+ + H2O Brucella abortus 9-941
-
betaine + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Brucella abortus Q57EI0 544
-
Brucella abortus 9-941 Q57EI0 544
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
betaine aldehyde + NAD+ + H2O
-
Brucella abortus betaine + NADH + H+
-
?
betaine aldehyde + NAD+ + H2O
-
Brucella abortus 9-941 betaine + NADH + H+
-
?
betaine aldehyde + NADP+ + H2O
-
Brucella abortus betaine + NADPH + H+
-
?
betaine aldehyde + NADP+ + H2O
-
Brucella abortus 9-941 betaine + NADPH + H+
-
?

Synonyms

Synonyms Comment Organism
BetB
-
Brucella abortus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Brucella abortus
NADP+
-
Brucella abortus

General Information

General Information Comment Organism
physiological function the betaine aldehyde dehydrogenase gene substantially affects the phagocytic pathway in human phagocytes and in host cells in mice. The enzyme is involved in the bacterial adherent ability to phagocytes and is responsible for the bacterial persistence and virulence in mice Brucella abortus