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Literature summary for 1.2.1.8 extracted from
- Characterization of partially purified betaine aldehyde dehydrogenase from horseshoe crab (Limulus polyphemus) cardiac mitochondria (1994), J. Exp. Zool., 270, 417-425.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | above 0.00075 mM | Limulus polyphemus |  |
| glycine betaine | - |
Limulus polyphemus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.133 | - |
Betaine aldehyde | - |
Limulus polyphemus | |
| 0.267 | - |
NADP+ | - |
Limulus polyphemus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Limulus polyphemus | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | increase of concentration from 0 to 0.00075 mM produces a 2fold increase in activity | Limulus polyphemus | |
| K+ | stimulates | Limulus polyphemus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| betaine aldehyde + NAD+ + H2O | Limulus polyphemus | - |
betaine + NADH | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Limulus polyphemus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Limulus polyphemus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 213 | - |
- |
Limulus polyphemus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| betaine aldehyde + NAD+ + H2O | - |
Limulus polyphemus | betaine + NADH | - |
? | |
| betaine aldehyde + NADP+ + H2O | - |
Limulus polyphemus | betaine + NADPH | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
- |
Limulus polyphemus |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 20 | 40 | 20°C: about 45% of maximal activity, 40°C: about 70% of maximal activity | Limulus polyphemus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Limulus polyphemus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 8 | pH 7.0: about 35% of maximal activity, pH 8.0: about 70% of maximal activity | Limulus polyphemus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | NAD+ is preferred over NADP+ | Limulus polyphemus | |
| NADP+ | NAD+ is preferred over NADP+ | Limulus polyphemus | |
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