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Literature summary for 1.2.1.8 extracted from

  • Chern, M.K.; Pietruszko, R.
    Evidence for mitochondrial localization of betaine aldehyde dehydrogenase in rat liver: purification, characterization, and comparison with human cytoplasmic E3 isozyme (1999), Biochem. Cell Biol., 77, 179-187.
    View publication on PubMed
Search for more literature for 1.2.1.8

Inhibitors

Inhibitors Comment Organism Structure
cimetidine
-
 Homo sapiens
cimetidine
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.004
-
 4-Aminobutyraldehyde mitochondrial enzyme Rattus norvegicus
0.005
-
 4-Aminobutyraldehyde
-
 Homo sapiens
0.014
-
 acetaldehyde
-
 Rattus norvegicus
0.034
-
 NAD+ mitochondrial enzyme Rattus norvegicus
0.035
-
 NAD+
-
 Homo sapiens
0.05
-
 acetaldehyde
-
 Homo sapiens
0.118
-
 Betaine aldehyde mitochondrial enzyme Rattus norvegicus
0.153
-
 glycolaldehyde
-
 Rattus norvegicus
0.24
-
 glycolaldehyde
-
 Homo sapiens
0.26
-
 Betaine aldehyde
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Rattus norvegicus 5737
-
cytoplasm NAD+-linked aldehyde dehydrogenase E3 isoenzyme Homo sapiens 5737
-
mitochondrion
-
 Rattus norvegicus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
53000
-
 x * 53000 + x * 59000, SDS-PAGE Rattus norvegicus
54000
-
 x * 54000, SDS-PAGE Homo sapiens
59000
-
 x * 53000 + x * 59000, SDS-PAGE Rattus norvegicus
230000
-
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
betaine aldehyde + NAD+ + H2O Rattus norvegicus the enzyme has an important function in the metabolism of choline to betaine, a major osmolyte. Betaine is also important in mammalian organisms as a major methyl group donor and nitrogen source betaine + NADH
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 aldehyde dehydrogenase E3 isoenzyme is a betaine aldehyde dehydrogenase
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.3
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-aminobutyraldehyde + NAD+ + H2O
-
 Homo sapiens 4-aminobutyrate + NADH
-
 ?
4-aminobutyraldehyde + NAD+ + H2O
-
 Rattus norvegicus 4-aminobutyrate + NADH
-
 ?
acetaldehyde + NAD+ + H2O
-
 Homo sapiens acetate + NADH + H+
-
 ?
acetaldehyde + NAD+ + H2O
-
 Rattus norvegicus acetate + NADH + H+
-
 ?
betaine aldehyde + NAD+ + H2O
-
 Homo sapiens betaine + NADH
-
 ?
betaine aldehyde + NAD+ + H2O
-
 Rattus norvegicus betaine + NADH
-
 ?
betaine aldehyde + NAD+ + H2O the enzyme has an important function in the metabolism of choline to betaine, a major osmolyte. Betaine is also important in mammalian organisms as a major methyl group donor and nitrogen source Rattus norvegicus betaine + NADH
-
 ?
glycolaldehyde + NAD+ + H2O
-
 Homo sapiens glycolate + NADH
-
 ?
glycolaldehyde + NAD+ + H2O
-
 Rattus norvegicus glycolate + NADH
-
 ?

Subunits

Subunits Comment Organism
? x * 54000, SDS-PAGE Homo sapiens
? x * 53000 + x * 59000, SDS-PAGE Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.001
-
 cimetidine
-
 Homo sapiens
0.033
-
 cimetidine
-
 Rattus norvegicus