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Literature summary for 1.2.1.70 extracted from

  • Randau, L.; Schauer, S.; Ambrogelly, A.; Salazar, J.C.; Moser, J.; Sekine, S.; Yokoyama, S.; Soll, D.; Jahn, D.
    tRNA recognition by glutamyl-tRNA reductase (2004), J. Biol. Chem., 279, 34931-34937.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamyl-tRNAGlu + NADPH + H+ Escherichia coli the enzyme catalyzes the initial step of tetrapyrrole biosynthesis L-glutamate 1-semialdehyde + NADP+ + tRNAGlu
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Organism

Organism UniProt Comment Textmining
Escherichia coli
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamyl-tRNAGlu + NADPH + H+ the enzyme catalyzes the initial step of tetrapyrrole biosynthesis Escherichia coli L-glutamate 1-semialdehyde + NADP+ + tRNAGlu
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?
L-glutamyl-tRNAGlu + NADPH + H+ the enzyme interacts directly with the amino-acylated acceptor stem and the D-stem, whereas the anticodon domain serves as a major recognition element of aminoacyl tRNA synthetases Escherichia coli L-glutamate 1-semialdehyde + NADP+ + tRNAGlu
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Cofactor

Cofactor Comment Organism Structure
NADPH
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Escherichia coli