Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
T186S | the mutant has increased activity against aldehyde and decreased activity against smaller substrates like benzaldehyde compared to the native enzyme and cells transformed with the point mutant are better protected against the killing effect of cyclophosphamides | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P30838 | - |
- |
Purification (Comment) | Organism |
---|---|
nickel affinity column chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
stomach | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetaldehyde + NADP+ + H2O | - |
Homo sapiens | acetate + NADPH + H+ | - |
? | |
mafosfamide + NADP+ + H2O | - |
Homo sapiens | ? | - |
? | |
p-hydroxybenzaldehyde + NADP+ + H2O | - |
Homo sapiens | p-hydroxybenzoic acid + NADPH + H+ | - |
? | |
p-nitrobenzaldehyde + NADP+ + H2O | - |
Homo sapiens | p-nitrobenzoate + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ALDH3 | - |
Homo sapiens |
class 3 aldehyde dehydrogenase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens |