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Literature summary for 1.2.1.5 extracted from

  • Izaguirre, G.; Pietruszko, R.; Cho, S.; MacKerell, A.D., Jr.
    Human aldehyde dehydrogenase catalytic activity and structural interactions with coenzyme analogs (2001), J. Biomol. Struct. Dyn., 19, 429-447.
    View publication on PubMed
Search for more literature for 1.2.1.5

Inhibitors

Inhibitors Comment Organism Structure
3-thionicotinamide adenine dinucleotide strong inhibition versus beta-NAD+, isoenzyme E2; substrate inhibition, isoenzyme E1 Homo sapiens
beta-NADP+ substrate inhibition, isoenzyme E1 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0047
-
 beta-NAD+
-
 Homo sapiens
0.0113
-
 N-1,N6-ethenoadenine dinucleotide isoenzyme E1 Homo sapiens
0.0132
-
 3-acetylpyridine adenine dinucleotide isoenzyme E1 Homo sapiens
0.0151
-
 3-thionicotinamide adenine dinucleotide isoenzyme E1 Homo sapiens
0.0338
-
 3-pyridinealdehyde adenine dinucleotide isoenzyme E2 Homo sapiens
0.094
-
 betaNAD+ isoenzyme E2 Homo sapiens
0.096
-
 1,N6-ethenoadenine dinucleotide isoenzyme E2 Homo sapiens
0.121
-
 oxidized nicotinamide hypoxanthine dinucleotide isoenzyme E1 Homo sapiens
0.504
-
 3-pyridinealdehyde adenine dinucleotide isoenzyme E1 Homo sapiens
0.62
-
 3-acetylpyridine adenine dinucleotide isoenzyme E2 Homo sapiens
1.33
-
 N-guanine dinucleotide isoenzyme E1 Homo sapiens
1.36
-
 oxidized nicotinamide hypoxanthine dinucleotide isoenzyme E2 Homo sapiens
7.68
-
 beta-NADP+ isoenzyme E1 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isoenzyme E1 and E2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
propanal + 1,N6-ethenoadenine dinucleotide isoenzyme E1 and E2 Homo sapiens propionate + ?
-
 ?
propanal + 3-acetylpyridine adenine dinucleotide isoenzyme E1 and E2 Homo sapiens propionate + ?
-
 ?
propanal + 3-pyridine adenine dinucleotide isoenzyme E1 and E2 Homo sapiens propionate + ?
-
 ?
propanal + 3-thionicotinamide adenine dinucleotide isoenzyme E1 Homo sapiens propionate + ?
-
 ?
propanal + 3-thionicotinamide adenine dinucleotide no reaction with isoenzyme E2 Homo sapiens propionate + ?
-
 ?
propanal + beta-NADP+ + H2O isoenzyme E1 and E2 Homo sapiens propionate + beta-NADPH + H+
-
 ?
propanal + N-guanine dinucleotide isoenzyme E1 and E2 Homo sapiens propionate + ?
-
 ?
propanal + NAD+ + H2O
-
 Homo sapiens propionate + NADH + H+
-
 ?
propanal + oxidized nicotinamide hypoxanthine dinucleotide + H2O isoenzyme E1 and E2 Homo sapiens propionate + reduced nicotinamide hypoxanthine dinucleotide
-
 ?
propionaldehyde + 3-pyridinealdehyde adenine dinucleotide + H2O
-
 Homo sapiens propionate + reduced 3-pyridinealdehyde adenine dinucleotide + H+
-
 r
propionaldehyde + N-1,N6-ethenoadenine dinucleotide + H2O
-
 Homo sapiens propionate + reduced N-1,N6-ethenoadenine dinucleotide + H+
-
 ?