Cloned (Comment) | Organism |
---|---|
detection of three Mgd loci, which show a restrictive tissue expression, Mgd1 and Mgd2 are preferentially expressed in liver and kidney, Mgd3 is expressed apparently exclusively in heart | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
methylglyoxal + NADP+ + H2O | Rattus norvegicus | - |
pyruvate + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
inbred strains, recombinant inbred strains | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Rattus norvegicus | - |
kidney | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-oxoaldehydes + NADP+ + H2O | - |
Rattus norvegicus | 2-oxo acids + NADPH | - |
? | |
methylglyoxal + NADP+ + H2O | - |
Rattus norvegicus | pyruvate + NADPH + H+ | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | Mgd1 and Mgd2 enzymes use also NAD+ as cofactor, see also EC 1.2.1.23 | Rattus norvegicus | |
NADP+ | isoenzyme Mgd3 is exclusively NADP+-dependent | Rattus norvegicus |