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Literature summary for 1.2.1.49 extracted from

  • Ray, S.; Ray, M.
    Purification and characterization of NAD and NADP-linked alpha-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate (1982), J. Biol. Chem., 257, 10566-10570.
    View publication on PubMed
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.04
-
 NADP+
-
 Capra hircus
0.21 0.83 methylglyoxal
-
 Capra hircus
0.5
-
 methylglyoxal
-
 Capra hircus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42000
-
 gel filtration Capra hircus
43000
-
 1 * 43000, SDS-PAGE Capra hircus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
methylglyoxal + NADP+ + H2O Capra hircus
-
 pyruvate + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Capra hircus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Capra hircus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Capra hircus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.6
-
-
 Capra hircus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoaldehydes + NADP+ + H2O
-
 Capra hircus 2-oxo acids + NADPH
-
 ?
methylglyoxal + NADP+ + H2O
-
 Capra hircus pyruvate + NADPH + H+
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 43000, SDS-PAGE Capra hircus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
 Capra hircus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Capra hircus