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Literature summary for 1.2.1.48 extracted from

  • Kitamura, T.; Naganuma, T.; Abe, K.; Nakahara, K.; Ohno, Y.; Kihara, A.
    Substrate specificity, plasma membrane localization, and lipid modification of the aldehyde dehydrogenase ALDH3B1 (2013), Biochim. Biophys. Acta, 1831, 1395-1401.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in FAA-K1A cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hexadecanal + NAD+ + H2O Homo sapiens high activity hexadecanoic acid + NADH
-
?
trans-2-hexadecenal + NAD+ + H2O Homo sapiens
-
trans-2-decenoic acid + NADH
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
palmitoylation
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hexadecanal + NAD+ + H2O high activity Homo sapiens hexadecanoic acid + NADH
-
?
trans-2-hexadecenal + NAD+ + H2O
-
Homo sapiens trans-2-decenoic acid + NADH
-
?

Synonyms

Synonyms Comment Organism
Aldh3b1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens

General Information

General Information Comment Organism
malfunction ALDH3B1 does not cause further impairment of the sphingolipid metabolism in the ALDH3A2-deficient cells Homo sapiens
metabolism the enzyme is not involved in the long-chain base metabolism Homo sapiens
physiological function the likely physiological function of ALDH3B1 is to oxidize lipid-derived aldehydes generated in the plasma membrane Homo sapiens