Literature summary for 1.2.1.48 extracted from

Ahvazi, B.; Coulombe, R.; Delarge, M.; Vedadi, M.; Zhang, L.; Meighen, E.; Vrielink, A.
Crystal structure of the NADP+-dependent aldehyde dehydrogenase from Vibrio harveyi: structural implications for cofactor specificity and affinity (2000), Biochem. J., 349, 853-861.

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Organism

Organism	UniProt	Comment	Textmining
Vibrio harveyi	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
long-chain aldehyde + NAD+ + H2O	-	Vibrio harveyi	long-chain acid anion + NADH	-	?

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	very high specificity and affinity, the residue Arg-210 contributes to the high cofactor affinity through a pi stacking interaction with the adenine ring system of the cofactor	Vibrio harveyi

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Release 2023.1 (January 2023)