Protein Variants | Comment | Organism |
---|---|---|
D77A | the mutant shows specificity towards coumaroyl-CoA | Leucaena leucocephala |
D77G | the mutant displays equal affinity for caffeoyl-CoA and sinapoyl-CoA | Leucaena leucocephala |
D77N | the mutant has same substrate affinity (feruloyl CoA) as that of wild type enzyme | Leucaena leucocephala |
F30L | the mutant shows preference for coumaroyl-CoA | Leucaena leucocephala |
F30S | the mutant shows preference for coumaroyl-CoA | Leucaena leucocephala |
F30V | the mutant prefers feruloyl-CoA as favoured substrate | Leucaena leucocephala |
F30Y | the mutant shows preference for coumaroyl-CoA | Leucaena leucocephala |
H215L | the mutant displays preference for sinapoyl-CoA | Leucaena leucocephala |
H215R | coumaroyl-CoA is specific for mutant H215R | Leucaena leucocephala |
H215Y | 5-hydroxyferuloyl-CoA is specific for mutant H215Y | Leucaena leucocephala |
I31F | the mutant shows more negative binding energy for hydroxyferuloyl CoA | Leucaena leucocephala |
I31M | the mutant exhibits equal affinity for coumaroyl and hydroxyferulol CoA | Leucaena leucocephala |
I31N | the mutant demonstrates better affinity for sinapoyl CoA over others | Leucaena leucocephala |
K174E | the mutant shows coumaroyl-CoA as preferred substrate | Leucaena leucocephala |
K174M | the mutant is specific for feruloyl CoA | Leucaena leucocephala |
K174N | the mutant has favorable binding energy for hydroxyferuloyl-CoA | Leucaena leucocephala |
K174R | the mutant has favorable binding energy for hydroxyferuloyl-CoA | Leucaena leucocephala |
K174T | the mutant shows coumaroyl-CoA as preferred substrate | Leucaena leucocephala |
R51G | the mutation alters side chain from polar charged to small compact neutral residue, resulting in marked decrease in accessible surface area and leads to loss of interactions with substrate | Leucaena leucocephala |
R51K | the mutant shows affinity towards caffeoyl-CoA | Leucaena leucocephala |
S136A | coumaroyl CoA is a better substrate for mutant S136A | Leucaena leucocephala |
S136C | coumaroyl CoA is a better substrate for mutant S136C | Leucaena leucocephala |
S136P | the mutant shows favored specificity for feruloyl-CoA | Leucaena leucocephala |
S136T | the mutant shows favored specificity for feruloyl-CoA | Leucaena leucocephala |
S136Y | the mutant shows preference for caffeoyl-CoA | Leucaena leucocephala |
S212T | the mutant shows feruloyl CoA as promising substrate | Leucaena leucocephala |
V200A | the mutant displays substrate specificity towards coumaroyl-CoA | Leucaena leucocephala |
V200G | the mutant displays substrate specificity towards coumaroyl-CoA | Leucaena leucocephala |
V200M | the mutant exhibits increased affinity for coumaroyl-CoA | Leucaena leucocephala |
Y170C | the mutant displays less number of interactions compared to the wild type enzyme | Leucaena leucocephala |
Y170F | the mutant shows preference for coumaroyl-CoA | Leucaena leucocephala |
Y170H | the mutant demonstrates affinity for feruloyl-CoA | Leucaena leucocephala |
Y170N | the mutant shows preference for coumaroyl-CoA | Leucaena leucocephala |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-coumaroyl-CoA + NADPH + H+ | Leucaena leucocephala | - |
4-coumaric aldehyde + CoA + NADP+ | - |
? | |
5-hydroxyferuloyl-CoA + NADPH + H+ | Leucaena leucocephala | - |
5-hydroxyconiferaldehyde + CoA + NADP+ | - |
? | |
caffeoyl-CoA + NADPH + H+ | Leucaena leucocephala | - |
caffealdehyde + CoA + NADP+ | - |
? | |
cinnamaldehyde + CoA + NADP+ | Leucaena leucocephala | - |
cinnamoyl-CoA + NADPH + H+ | - |
? | |
feruloyl-CoA + NADPH + H+ | Leucaena leucocephala | most favoured substrate | coniferaldehyde + CoA + NADP+ | - |
? | |
sinapoyl-CoA + NADPH + H+ | Leucaena leucocephala | - |
sinapaldehyde + CoA + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leucaena leucocephala | Q08GL0 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-coumaroyl-CoA + NADPH + H+ | - |
Leucaena leucocephala | 4-coumaric aldehyde + CoA + NADP+ | - |
? | |
5-hydroxyferuloyl-CoA + NADPH + H+ | - |
Leucaena leucocephala | 5-hydroxyconiferaldehyde + CoA + NADP+ | - |
? | |
caffeoyl-CoA + NADPH + H+ | - |
Leucaena leucocephala | caffealdehyde + CoA + NADP+ | - |
? | |
cinnamaldehyde + CoA + NADP+ | - |
Leucaena leucocephala | cinnamoyl-CoA + NADPH + H+ | - |
? | |
feruloyl-CoA + NADPH + H+ | most favoured substrate | Leucaena leucocephala | coniferaldehyde + CoA + NADP+ | - |
? | |
sinapoyl-CoA + NADPH + H+ | - |
Leucaena leucocephala | sinapaldehyde + CoA + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CCRH1 | - |
Leucaena leucocephala |
cinnamoyl CoA reductase 1 | - |
Leucaena leucocephala |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Leucaena leucocephala | |
NADPH | - |
Leucaena leucocephala |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme carries out the first committed step in monolignol biosynthesis and acts as a first regulatory point in lignin formation | Leucaena leucocephala |