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Literature summary for 1.2.1.44 extracted from

  • Sonawane, P.; Patel, K.; Vishwakarma, R.K.; Singh, S.; Khan, B.M.
    In silico mutagenesis and docking studies of active site residues suggest altered substrate specificity and possible physiological role of cinnamoyl CoA reductase 1 (Ll-CCRH1) (2013), Bioinformation, 9, 224-232.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
D77A the mutant shows specificity towards coumaroyl-CoA Leucaena leucocephala
D77G the mutant displays equal affinity for caffeoyl-CoA and sinapoyl-CoA Leucaena leucocephala
D77N the mutant has same substrate affinity (feruloyl CoA) as that of wild type enzyme Leucaena leucocephala
F30L the mutant shows preference for coumaroyl-CoA Leucaena leucocephala
F30S the mutant shows preference for coumaroyl-CoA Leucaena leucocephala
F30V the mutant prefers feruloyl-CoA as favoured substrate Leucaena leucocephala
F30Y the mutant shows preference for coumaroyl-CoA Leucaena leucocephala
H215L the mutant displays preference for sinapoyl-CoA Leucaena leucocephala
H215R coumaroyl-CoA is specific for mutant H215R Leucaena leucocephala
H215Y 5-hydroxyferuloyl-CoA is specific for mutant H215Y Leucaena leucocephala
I31F the mutant shows more negative binding energy for hydroxyferuloyl CoA Leucaena leucocephala
I31M the mutant exhibits equal affinity for coumaroyl and hydroxyferulol CoA Leucaena leucocephala
I31N the mutant demonstrates better affinity for sinapoyl CoA over others Leucaena leucocephala
K174E the mutant shows coumaroyl-CoA as preferred substrate Leucaena leucocephala
K174M the mutant is specific for feruloyl CoA Leucaena leucocephala
K174N the mutant has favorable binding energy for hydroxyferuloyl-CoA Leucaena leucocephala
K174R the mutant has favorable binding energy for hydroxyferuloyl-CoA Leucaena leucocephala
K174T the mutant shows coumaroyl-CoA as preferred substrate Leucaena leucocephala
R51G the mutation alters side chain from polar charged to small compact neutral residue, resulting in marked decrease in accessible surface area and leads to loss of interactions with substrate Leucaena leucocephala
R51K the mutant shows affinity towards caffeoyl-CoA Leucaena leucocephala
S136A coumaroyl CoA is a better substrate for mutant S136A Leucaena leucocephala
S136C coumaroyl CoA is a better substrate for mutant S136C Leucaena leucocephala
S136P the mutant shows favored specificity for feruloyl-CoA Leucaena leucocephala
S136T the mutant shows favored specificity for feruloyl-CoA Leucaena leucocephala
S136Y the mutant shows preference for caffeoyl-CoA Leucaena leucocephala
S212T the mutant shows feruloyl CoA as promising substrate Leucaena leucocephala
V200A the mutant displays substrate specificity towards coumaroyl-CoA Leucaena leucocephala
V200G the mutant displays substrate specificity towards coumaroyl-CoA Leucaena leucocephala
V200M the mutant exhibits increased affinity for coumaroyl-CoA Leucaena leucocephala
Y170C the mutant displays less number of interactions compared to the wild type enzyme Leucaena leucocephala
Y170F the mutant shows preference for coumaroyl-CoA Leucaena leucocephala
Y170H the mutant demonstrates affinity for feruloyl-CoA Leucaena leucocephala
Y170N the mutant shows preference for coumaroyl-CoA Leucaena leucocephala

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-coumaroyl-CoA + NADPH + H+ Leucaena leucocephala
-
4-coumaric aldehyde + CoA + NADP+
-
?
5-hydroxyferuloyl-CoA + NADPH + H+ Leucaena leucocephala
-
5-hydroxyconiferaldehyde + CoA + NADP+
-
?
caffeoyl-CoA + NADPH + H+ Leucaena leucocephala
-
caffealdehyde + CoA + NADP+
-
?
cinnamaldehyde + CoA + NADP+ Leucaena leucocephala
-
cinnamoyl-CoA + NADPH + H+
-
?
feruloyl-CoA + NADPH + H+ Leucaena leucocephala most favoured substrate coniferaldehyde + CoA + NADP+
-
?
sinapoyl-CoA + NADPH + H+ Leucaena leucocephala
-
sinapaldehyde + CoA + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Leucaena leucocephala Q08GL0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-coumaroyl-CoA + NADPH + H+
-
Leucaena leucocephala 4-coumaric aldehyde + CoA + NADP+
-
?
5-hydroxyferuloyl-CoA + NADPH + H+
-
Leucaena leucocephala 5-hydroxyconiferaldehyde + CoA + NADP+
-
?
caffeoyl-CoA + NADPH + H+
-
Leucaena leucocephala caffealdehyde + CoA + NADP+
-
?
cinnamaldehyde + CoA + NADP+
-
Leucaena leucocephala cinnamoyl-CoA + NADPH + H+
-
?
feruloyl-CoA + NADPH + H+ most favoured substrate Leucaena leucocephala coniferaldehyde + CoA + NADP+
-
?
sinapoyl-CoA + NADPH + H+
-
Leucaena leucocephala sinapaldehyde + CoA + NADP+
-
?

Synonyms

Synonyms Comment Organism
CCRH1
-
Leucaena leucocephala
cinnamoyl CoA reductase 1
-
Leucaena leucocephala

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Leucaena leucocephala
NADPH
-
Leucaena leucocephala

General Information

General Information Comment Organism
metabolism the enzyme carries out the first committed step in monolignol biosynthesis and acts as a first regulatory point in lignin formation Leucaena leucocephala