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Literature summary for 1.2.1.42 extracted from

  • Hellenbrand, J.; Biester, E.M.; Gruber, J.; Hamberg, M.; Frentzen, M.
    Fatty acyl-CoA reductases of birds (2011), BMC Biochem., 12, 64.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.42

Activating Compound

Activating Compound Comment Organism Structure
bovine serum albumin addition of 0.016 mM BSA into assays with 0.02 mM acyl-CoA gives about 5fold higher enzyme activity Tyto alba
bovine serum albumin addition of BSA into assays with 0.02 mM acyl-CoA gives about 5fold higher enzyme activity Gallus gallus
bovine serum albumin addition of BSA into assays with 0.02 mM acyl-CoA gives about 5fold higher enzyme activity Anser anser
Mg2+ addition of up to 1 mM MgCl2 stimulates the enzymatic activity 2fold Gallus gallus
Mg2+ addition of up to 1 mM MgCl2 stimulates the enzymatic activity 2fold Anser anser
Mg2+ addition of up to 1 mM MgCl2 stimulates the enzymatic activity 2fold Tyto alba

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Saccharomyces cerevisiae Gallus gallus
expressed in Saccharomyces cerevisiae Anser anser
expressed in Saccharomyces cerevisiae Tyto alba

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Gallus gallus 16020
-
membrane
-
 Anser anser 16020
-
membrane
-
 Tyto alba 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-methyl-1-hexadecanoyl-CoA + NADPH + H+ Gallus gallus
-
 2-methyl-1-hexadecanal + CoA + NADP+
-
 ?
2-methyl-1-hexadecanoyl-CoA + NADPH + H+ Anser anser
-
 2-methyl-1-hexadecanal + CoA + NADP+
-
 ?
2-methyl-1-hexadecanoyl-CoA + NADPH + H+ Tyto alba
-
 2-methyl-1-hexadecanal + CoA + NADP+
-
 ?
hexadecanoyl-CoA + NADPH + H+ Gallus gallus preferred substrate 1-hexadecanal + CoA + NADP+
-
 ?
hexadecanoyl-CoA + NADPH + H+ Anser anser preferred substrate 1-hexadecanal + CoA + NADP+
-
 ?
hexadecanoyl-CoA + NADPH + H+ Tyto alba preferred substrate 1-hexadecanal + CoA + NADP+
-
 ?
additional information Gallus gallus the enzyme is highly active with hexadecanoyl-CoA and shows lower activity with tetradecanoyl-CoA or octadecanoyl-CoA ?
-
 ?
additional information Anser anser the enzyme is highly active with hexadecanoyl-CoA and shows lower activity with tetradecanoyl-CoA or octadecanoyl-CoA ?
-
 ?
additional information Tyto alba the enzyme is highly active with hexadecanoyl-CoA and shows lower activity with tetradecanoyl-CoA or octadecanoyl-CoA ?
-
 ?

Organism

Organism UniProt Comment Textmining
Anser anser
-
-
-
Gallus gallus
-
-
-
Tyto alba
-
 barn owl
-

Source Tissue

Source Tissue Comment Organism Textmining
uropygial gland
-
 Gallus gallus
-
uropygial gland
-
 Anser anser
-
uropygial gland
-
 Tyto alba
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-methyl-1-hexadecanoyl-CoA + NADPH + H+
-
 Gallus gallus 2-methyl-1-hexadecanal + CoA + NADP+
-
 ?
2-methyl-1-hexadecanoyl-CoA + NADPH + H+
-
 Anser anser 2-methyl-1-hexadecanal + CoA + NADP+
-
 ?
2-methyl-1-hexadecanoyl-CoA + NADPH + H+
-
 Tyto alba 2-methyl-1-hexadecanal + CoA + NADP+
-
 ?
hexadecanoyl-CoA + NADPH + H+ preferred substrate Gallus gallus 1-hexadecanal + CoA + NADP+
-
 ?
hexadecanoyl-CoA + NADPH + H+ preferred substrate Anser anser 1-hexadecanal + CoA + NADP+
-
 ?
hexadecanoyl-CoA + NADPH + H+ preferred substrate Tyto alba 1-hexadecanal + CoA + NADP+
-
 ?
additional information the enzyme is highly active with hexadecanoyl-CoA and shows lower activity with tetradecanoyl-CoA or octadecanoyl-CoA Gallus gallus ?
-
 ?
additional information the enzyme is highly active with hexadecanoyl-CoA and shows lower activity with tetradecanoyl-CoA or octadecanoyl-CoA Anser anser ?
-
 ?
additional information the enzyme is highly active with hexadecanoyl-CoA and shows lower activity with tetradecanoyl-CoA or octadecanoyl-CoA Tyto alba ?
-
 ?

Synonyms

Synonyms Comment Organism
FAR1
-
 Gallus gallus
FAR1
-
 Anser anser
FAR1
-
 Tyto alba
fatty acyl-CoA reductase
-
 Gallus gallus
fatty acyl-CoA reductase
-
 Anser anser
fatty acyl-CoA reductase
-
 Tyto alba

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
37
-
 the enzymatic activity is constant for up to 15 min at 37°C Gallus gallus
37
-
 the enzymatic activity is constant for up to 15 min at 37°C Anser anser
37
-
 the enzymatic activity is constant for up to 15 min at 37°C Tyto alba

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
-
 Gallus gallus
6.5
-
-
 Anser anser
6.5
-
-
 Tyto alba

Cofactor

Cofactor Comment Organism Structure
NADPH dependent on Gallus gallus
NADPH dependent on Anser anser
NADPH dependent on Tyto alba