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Literature summary for 1.2.1.42 extracted from
- Solubilization, purification and characterization of fatty acyl-CoA reductase from duck uropygial gland (1995), Biochem. Biophys. Res. Commun., 208, 210-215.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| bovine serum albumin | 2 mg/ml, 5fold increase in enzyme activity | Anas platyrhynchos | |
| Lipids | 150% increase in activity | Anas platyrhynchos |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.029 | - |
hexadecanoyl-CoA | - |
Anas platyrhynchos |  |
| 0.067 | - |
NADPH | - |
Anas platyrhynchos | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Anas platyrhynchos | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 56000 | - |
x * 56000, SDS-PAGE | Anas platyrhynchos |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Anas platyrhynchos | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| solubilization from microsomal preparation with 20% glycerol and 3 M NaCl, affinity chromatography | Anas platyrhynchos |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| uropygial gland | - |
Anas platyrhynchos | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.033 | - |
- |
Anas platyrhynchos |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| hexadecanoyl-CoA + NAD(P)H | NADH gives almost 60% of the activity obtained with NADPH, after palmitoyl-CoA affinity column purification enzyme is absolutely dependent on NADPH as cofactor | Anas platyrhynchos | hexadecanal + NAD(P)+ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 56000, SDS-PAGE | Anas platyrhynchos |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD(P)H | after palmitoyl-CoA affinity column purification enzyme is absolutely dependent on NADPH as cofactor | Anas platyrhynchos | |
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