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Literature summary for 1.2.1.36 extracted from
- High-fat diet enhanced retinal dehydrogenase activity, but suppressed retinol dehydrogenase activity in liver of rats (2015), J. Pharmacol. Sci., 127, 430-438 .
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.166 | - |
NAD+ | microsomes, high-fate diet rats, pH and temperature not specified in the publication | Rattus norvegicus |  |
| 0.1822 | - |
NAD+ | microsomes, control rats, pH and temperature not specified in the publication | Rattus norvegicus | |
| 0.2269 | - |
NAD+ | cytosol, control rats, pH and temperature not specified in the publication | Rattus norvegicus | |
| 0.2424 | - |
NAD+ | cytosol, high-fate diet rats, pH and temperature not specified in the publication | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | mainly | Rattus norvegicus | 5829 | - |
| microsome | - |
Rattus norvegicus | - |
- |
| additional information | although both hepatic microsomes and cytosol exhibit RALDHs enzyme activity in the presence of NADP+ or NAD+, the contribution of hepatic microsomes to all-trans retinoic acid formation is less than that of hepatic cytosol. Hepatic cytosol catalyzes the oxidation of retinal into all-trans retinoic acid with NAD+ or NADP+ as cofactor, but the cytosolic RALDHs activity prefers NAD+, evidenced by greater contribution of NAD+-dependent all-trans retinoic acid formation | Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| all-trans-retinal + NAD+ + H2O | Rattus norvegicus | - |
all-trans-retinoate + NADH + 2 H+ | - |
? | |
| all-trans-retinal + NAD+ + H2O | Rattus norvegicus Sprague-Dawley | - |
all-trans-retinoate + NADH + 2 H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | P51647 | - |
- |
| Rattus norvegicus Sprague-Dawley | P51647 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose tissue | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| all-trans-retinal + NAD+ + H2O | - |
Rattus norvegicus | all-trans-retinoate + NADH + 2 H+ | - |
? | |
| all-trans-retinal + NAD+ + H2O | - |
Rattus norvegicus Sprague-Dawley | all-trans-retinoate + NADH + 2 H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| RALDH | - |
Rattus norvegicus |
| RalDH1 | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Rattus norvegicus | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Rattus norvegicus | enhanced activity and expression of RALDHs in liver of high-fat diet rats. High-fat diet feeding significantly up-regulates cytosolic RALDHs activity, 1.7fold and 2fold in the presence of NAD+ and NADP+, respectively | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | high-fat diet significantly decreases basal retinal levels in liver to 44% of control rats. Enhanced activity and expression of RALDHs in liver of high-fat diet rats | Rattus norvegicus |
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