Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.2.1.36 extracted from

  • Fujiwara, K.; Kikuchi, M.; Horiguchi, K.; Kusumoto, K.; Kouki, T.; Kawanishi, K.; Yashiro, T.
    Estrogen receptor alpha regulates retinaldehyde dehydrogenase 1 expression in rat anterior pituitary cells (2009), Endocr. J., 56, 963-973.
    View publication on PubMed
Search for more literature for 1.2.1.36

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
 SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P51647
-
-

Source Tissue

Source Tissue Comment Organism Textmining
anterior pituitary
-
 Rattus norvegicus
-
pituitary gland
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
retinal + NAD+ + H2O
-
 Rattus norvegicus retinoate + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
RalDH1
-
 Rattus norvegicus
retinaldehyde dehydrogenase 1
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus levels of RALDH1 gene expression and protein production markedly decrease after 1-week treatment with 17beta-estradiol in male rats. Treatment of isolated anterior pituitary cells with 17beta-estradiol (0.00001-10 nM) decreases expression of RALDH1 mRNA in a dose-dependent manner (about 55% RALDH1 mRNA level remaining 6 h after treatment with 10 nM 17beta-estradiol). 17beta-Estradiol-induced suppression of RALDH1 expression is completely blocked by the estrogen receptor antagonist ICI 182, 780. The ERalpha-selective agonist propylpyrazole triol (10 nM) mimicks the effect of 17beta-estradiol on RALDH1 expression, but the ERbeta-selective agonist diarylpropionitrile (10 nM) does not down