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Literature summary for 1.2.1.36 extracted from

  • Elizondo, G.; Medina-Diaz, I.M.; Cruz, R.; Gonzalez, F.J.; Vega, L.
    Retinoic acid modulates retinaldehyde dehydrogenase 1 gene expression through the induction of GADD153-C/EBPbeta interaction (2009), Biochem. Pharmacol., 77, 248-257.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
retinal + NAD+ + H2O Mus musculus
-
 retinoate + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hepa-1 cell
-
 Mus musculus
-
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
retinal + NAD+ + H2O
-
 Mus musculus retinoate + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
RalDH1
-
 Mus musculus
retinaldehyde dehydrogenase 1
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus high retinoic acid levels inhibit Raldh1 gene expression by sequestering CCAAT/enhancer binding protein beta through its interaction to GADD153. A decrease in Raldh1 mRNA levels in the aryl hydrocarbon receptor-null liver relative to wild type mouse liver is observed down