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Literature summary for 1.2.1.36 extracted from
- Effect of coenzymes and thyroid hormones on the dual activities of Xenopus cytosolic thyroid-hormone-binding protein (xCTBP) with aldehyde dehydrogenase activity (2002), Eur. J. Biochem., 269, 2257-2264.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cholecalciferol | 0.2 mM, activation to 136% of the control | Xenopus laevis |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of xCTBP/xALDH1 in Escherichia coli | Xenopus laevis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3,3',5-Triiodothyroacetic acid | 0.001 mM, 60% inhibition | Xenopus laevis | |
| D-3,3',5-triiodothyronine | 0.001 mM, 65% inhibition | Xenopus laevis | |
| Disulfiram | 0.2 mM, 58% inhibition | Xenopus laevis | |
| L-thyroxine | 0.001 mM, 64% inhibition | Xenopus laevis | |
| NADH | 0.2 mM, 62% inhibition | Xenopus laevis | |
| NADPH | 0.2 mM, 79% inhibition | Xenopus laevis | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Xenopus laevis | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Xenopus laevis | the enzyme xCTBP/xALDH1 binds T3 within living cells | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Xenopus laevis | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Xenopus laevis | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme xCTBP/xALDH1 binds T3 within living cells | Xenopus laevis | ? | - |
? | |
| retinal + NAD+ + H2O | - |
Xenopus laevis | retinoic acid + NADH | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ALDH1 | - |
Xenopus laevis |
| thyroid-hormone-binding protein | - |
Xenopus laevis |
| xCTBP | - |
Xenopus laevis |
| xCTBP/xALDH1 | - |
Xenopus laevis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Xenopus laevis | |
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