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Literature summary for 1.2.1.36 extracted from

  • Leo, M.A.; Kim, C.I.; Lowe, N.; Lieber, C.S.
    Increased hepatic retinal dehydrogenase activity after phenobarbital and ethanol administration (1989), Biochem. Pharmacol., 38, 97-103.
    View publication on PubMed
Search for more literature for 1.2.1.36

Inhibitors

Inhibitors Comment Organism Structure
acetaldehyde 0.2 mM, 0.5 mM and 1.0 mM, uncompetitive inhibition Rattus norvegicus
Chloral hydrate noncompetitive inhibition Rattus norvegicus
Disulfiram 20 mM Rattus norvegicus
NaCN
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.066
-
 retinal
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
retinal + NAD+ + H2O Rattus norvegicus
-
 retinoate + NADH
-
 ?
retinal + NAD+ + H2O Rattus norvegicus BR
-
 retinoate + NADH
-
 ?

Organism

Organism UniProt Comment Textmining
Peromyscus maniculatus
-
 deermouse
-
Rattus norvegicus
-
 Sprague-Dawley, BR strain
-
Rattus norvegicus BR
-
 Sprague-Dawley, BR strain
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
retinal + NAD+ + H2O
-
 Rattus norvegicus retinoate + NADH
-
 ?
retinal + NAD+ + H2O
-
 Rattus norvegicus BR retinoate + NADH
-
 ?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0126
-
 Chloral hydrate
-
 Rattus norvegicus
0.53
-
 acetaldehyde standard deviation 0.01 mM Rattus norvegicus