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Literature summary for 1.2.1.31 extracted from

  • Rodwell, V.W.
    delta1-piperideine-6-carboxylic acid and alpha-aminoadipic acid delta-semialdehyde (1971), Methods Enzymol., 17B, 188-199.
No PubMed abstract available
Search for more literature for 1.2.1.31

Inhibitors

Inhibitors Comment Organism Structure
ATP 30% inhibition at 1 mM Pseudomonas putida
carbonyl reagents e.g.: hydroxylamine, KCN, in the presence of substrate Pseudomonas putida
HSO3- in presence of substrate Pseudomonas putida
hydroxylamine in presence of substrate Pseudomonas putida
KCN in presence of substrate Pseudomonas putida

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.002
-
 DELTA1-piperidine 6-carboxylate
-
 Pseudomonas putida

Metals/Ions

Metals/Ions Comment Organism Structure
additional information no metal cofactor required Pseudomonas putida

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-2-aminoadipate-semialdehyde + NAD+ Pseudomonas putida degradative enzyme L-2-aminoadipate + NADH
-
 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas putida
-
-
-

Purification (Commentary)

Purification (Comment) Organism
using protamine sulfate treatment, ammonium sulfate fractionation and treatment with calcium phosphate gel Pseudomonas putida

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.9
-
 after purification, gel fraction Pseudomonas putida

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-2,3,4,5-tetrahydropyridine-2-carboxylate + NAD+ + H2O
-
 Pseudomonas putida L-2-aminoadipate + NADH
-
 ir
DELTA1-piperidine 6-carboxylate + NAD+ + H2O
-
 Pseudomonas putida L-alpha-aminoadipate + NADH + H+
-
 r
L-2-aminoadipate 6-semialdehyde + NAD+ + H2O
-
 Pseudomonas putida L-2-aminoadipate + NADH
-
 ir
L-2-aminoadipate-semialdehyde + NAD+ degradative enzyme Pseudomonas putida L-2-aminoadipate + NADH
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.1
-
 L-alpha-aminoadipate-semialdehyde reduction Pseudomonas putida

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Pseudomonas putida