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Literature summary for 1.2.1.31 extracted from
- Degradation of O-phosphohydroxylysine in rat liver. Purification and properties of 2-aminoadipic semialdehyde dehydrogenase (1974), J. Biol. Chem., 249, 5790-5792.
General Stability
| General Stability | Organism |
|---|---|
| freezing-thawing, frozen enzyme loses 10-20% of activity during each freeze-thaw cycle | Rattus norvegicus |
| lyophilization inactivates | Rattus norvegicus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.02 | - |
2-aminoadipic semialdehyde | - |
Rattus norvegicus |  |
| 0.2 | - |
NAD+ | - |
Rattus norvegicus | |
| 0.2 | - |
alpha-aminoadipate | NAD+ | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Rattus norvegicus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 250000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-2-aminoadipate-semialdehyde + NAD+ | Rattus norvegicus | mammalian degradation of hydroxy-L-lysine via phosphohydrolysine and 2-aminoadipic semialdehyde to 2-aminoadipic acid | L-2-aminoadipate + NADH | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| using ammonium sulfate fractionation and column chromatography on CM-Sephadex | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.185 | - |
- |
Rattus norvegicus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 0°C, 50% loss of activity, 24 h | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-aminoadipic semialdehyde + NAD+ + H2O | - |
Rattus norvegicus | alpha-aminoadipic acid + NADH + H+ | - |
? | |
| L-2-aminoadipate 6-semialdehyde + NAD+ + H2O | - |
Rattus norvegicus | L-2-aminoadipate + NADH | - |
? | |
| L-2-aminoadipate-semialdehyde + NAD+ | mammalian degradation of hydroxy-L-lysine via phosphohydrolysine and 2-aminoadipic semialdehyde to 2-aminoadipic acid | Rattus norvegicus | L-2-aminoadipate + NADH | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 9 | pH 5: about 30% of activity maximum, pH 9: about 40% of activity maximum | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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