Any feedback?
Literature summary for 1.2.1.31 extracted from
- Properties of revertants of lys2 and lys5 mutants as well as alpha-aminoadipate-semialdehyde dehydrogenase from Saccharomyces cerevisiae (1989), Biochem. Biophys. Res. Commun., 161, 182-186.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| encoded by two different genes, LYS2 and LYS5 | Saccharomyces cerevisiae |
General Stability
| General Stability | Organism |
|---|---|
| addition of 10 mM 2-mercaptoethanol and protease inhibitors e.g.: 5 mM EDTA, 1 mM phenylmethylsulfonyl fluoride to the crude extract improves stability | Saccharomyces cerevisiae |
| low ionic strength: unstable | Saccharomyces cerevisiae |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required for activity | Saccharomyces cerevisiae |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 180000 | - |
gel filtration | Saccharomyces cerevisiae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-alpha-aminoadipate + NAD(P)H | Saccharomyces cerevisiae | in presence of ATP and Mg2+ | L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? | |
| L-alpha-aminoadipate + NAD(P)H | Saccharomyces cerevisiae | sixth step of lysine biosynthesis | L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial, using column chromatography on DEAE-cellulose, gel filtration, hydrolxylapatite and Reactive Red-120 agarose | Saccharomyces cerevisiae |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-2-aminoadipate + NADPH | in presence of ATP + Mg2+ | Saccharomyces cerevisiae | L-2-aminoadipate 6-semialdehyde + NADP+ + H2O | - |
? | |
| L-alpha-aminoadipate + NAD(P)H | in presence of ATP and Mg2+ | Saccharomyces cerevisiae | L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? | |
| L-alpha-aminoadipate + NAD(P)H | sixth step of lysine biosynthesis | Saccharomyces cerevisiae | L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| -70 | - |
unstable | Saccharomyces cerevisiae |
| -20 | - |
unstable | Saccharomyces cerevisiae |
| 4 | - |
unstable | Saccharomyces cerevisiae |
| 30 | - |
unstable | Saccharomyces cerevisiae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Saccharomyces cerevisiae | |
| NADPH | - |
Saccharomyces cerevisiae | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2026.1 (March 2026)
Legal
Curated at
Member of
![DSMZ Digital Diversity]()
![Global Core Biodata Resource]()
![ELIXIR Core Data Resource]()
![German Network for Bioinformatics Infrastructure]()
