Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2-mercaptoethanol | 10 mM, activates | Homo sapiens | |
dithiothreitol | 10 mM, activates | Homo sapiens | |
L-cysteine | 10 mM, activates | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EDTA | - |
Homo sapiens | |
FeCl3 | - |
Homo sapiens | |
KCN | strongly inhibits, 75% inhibition | Homo sapiens | |
Pb(NO3)2 | - |
Homo sapiens | |
Sodium diphosphate | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.181 | - |
L-2-aminoadipate 6-semialdehyde | - |
Homo sapiens | |
0.454 | - |
NAD+ | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | stimulates | Homo sapiens | |
Mg2+ | stimulates | Homo sapiens | |
Mn2+ | stimulates | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00077 | - |
cytosol fraction | Homo sapiens |
Storage Stability | Organism |
---|---|
-20°C, 0.02 mM potassium phosphate buffer, pH 7.0, 5 mM 2-mercaptoethanol, 3 months | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-2-aminoadipate 6-semialdehyde + NAD+ + H2O | - |
Homo sapiens | L-2-aminoadipate + NADH | - |
ir |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
in 0.2 M Tris-glycine buffer containing 5 mM beta-mercaptoethanol, L-alpha-aminoadipate-semialdehyde reduction | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |