Literature summary for 1.2.1.3 extracted from

Hink, U.; Daiber, A.; Kayhan, N.; Trischler, J.; Kraatz, C.; Oelze, M.; Mollnau, H.; Wenzel, P.; Vahl, C.F.; Ho, K.K.; Weiner, H.; Munzel, T.
Oxidative inhibition of the mitochondrial aldehyde dehydrogenase promotes nitroglycerin tolerance in human blood vessels (2007), J. Am. Coll. Cardiol., 50, 2226-2232.

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Inhibitors

Inhibitors	Comment	Organism	Structure
benomyl	-	Homo sapiens
nitroglycerin	intravenous nitroglycerin treatment inhibits ALDH-2 activity, activity can be restored using dithiothreitol	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Homo sapiens	5739	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P05091	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood vessel	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-hydroxy-3-nitrobenzaldehyde + NAD+ + H2O	-	Homo sapiens	2-hydroxy-3-nitrobenzoic acid + NADH + H+	-	?
benzaldehyde + NAD+ + H2O	-	Homo sapiens	benzoate + NADH + H+	-	?

Synonyms

Synonyms	Comment	Organism
ALDH-2	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Homo sapiens

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Release 2023.1 (January 2023)